The Role of Adipose-Derived Stem Cells in Breast Cancer Progression and Metastasis

Table 1

Most common human BCC lines used for investigation of ADSC/breast cancer interaction [68, 69, 191].

BCC line	Classification	ER	PR	Her2	In culture	Notes	References
MCF-7	Luminal A	+	±	−	Mass	Endocrine responsive; Isolated from MPE	[36, 42, 46, 47, 50, 58, 61, 70–73, 98, 109]
MDA-MB-231	Basal B, claudin-low	−	−	−	Stellate	Isolated from MPE	[22, 30, 36, 38, 42, 49, 71–74, 89, 109]
T47D	Luminal A	+	±	−	Mass	Endocrine responsive; Isolated from MPE	[70, 73, 93]
BT-474	Luminal B	+	+	+	Mass	Endocrine and Trastuzumab responsive; Isolated from primary tumor	[70, 71]
HCC1937	Basal A	−	−	−	n/a	Isolated from primary tumor	[41, 43]
MDA-MB-436	Basal B	−	−	−	Stellate	Isolated from MPE	[41, 43]
ZR 75.1	Luminal B	+	±	+	Grape-like	Endocrine and Trastuzumab responsive. Isolated from ascites	[39, 41]
SKBR3	Luminal, Her2	−	−	+	Grape-like	Trastuzumab responsive; Isolated from MPE	[23]
T4-2 (HMT-3522)	Basal B	−	−	−	Mass	Isolated from primary tumor	[74]

BC: breast cancer; BCC: breast cancer cell; ER: estrogen receptor; Her2: human epidermal growth factor receptor 2; MPE: metastatic pleural effusion; n.s.: not specified; PR: progesterone receptor.