Cell Therapy Augments Functional Recovery Subsequent to Spinal Cord Injury under Experimental Conditions

Table 1

Preclinical spinal cord injury trials using induced pluripotent stem cells (iPSCs)/embryonic stem cells (ESCs).

Transplanted cell type	SCI model	Neuronal regeneration	Functional recovery	Inflammation repression	Reference
mESCs	Mice, T8, contusion	—	Yes	Yes	[19]
mESCs + mMSCs	Mice, T9-10, contusion	Yes	—	—	[20]
mESCs-neurosphere	Mice, T10, contusion	Yes	Yes	—	[21]
hiPSCs-neuroepithelial cells	Mice, T10, contusion	Yes	Yes	—	[22]
hiPSCs-neural cells	Marmoset, C5, contusion	Yes	Yes	—	[23]
L1-mESCs-neural cells	Mice, T9, compression	Yes	Yes	Yes	[24]
Ngn2-hESCs	Rats, T9, compression	Yes	Yes	—	[25]
hECSs-NPCs	Rats, T10, hemisection	Yes	Yes	—	[26]
hESCs-NPCs + SCs	Rat, T9, contusion	Yes	Yes	—	[27]
hESCs-MPCs	Rat, C5-C6, contusion	Yes	Yes	—	[28]
hESCs-OPCs	Rat, T10, contusion	Yes	Yes	—	[29]
hESCs-OPCs	Rat, T9, contusion	Yes	Yes	—	[30]
hESCs-OPCs	Rat, C5, contusion	Yes	Yes	Yes	[31]
hESCs-MPCs/OPCs	Rat, T8, complete transection	Yes	Yes	—	[32]
hESCs-MPCs + OECs	Rat, T9, complete transection	Yes	Yes	—	[33]
mESCs-GABAergic	Rat, T13, lateral hemisection	Yes	Yes	—	[34]

Mouse embryonic stem cells (mESCs); human embryonic stem cells (hESCs); human induced pluripotent stem cells (hiPSCs); neural progenitor cells (NPCs); Schwann cells (SCs); neurogenin 2 (Ngn2); motoneuron progenitor cells (MPCs); oligodendrocyte progenitor cells (OPCs); olfactory ensheathing cells (OECs).