Review Article
Cell Therapy Augments Functional Recovery Subsequent to Spinal Cord Injury under Experimental Conditions
Table 3
Preclinical spinal cord injury trials using neural stem cells (NSCs)/neural progenitor cells (NPCs).
| | Transplanted cell type | SCI model | Neuronal regeneration | Functional recovery | Inflammation repression | Reference |
| | Fetal-mNSCs | Mice, T10, contusion | Yes | Yes | — | [59] | | Fetal-rNSCs | Rats, C4, dorsal hemisection | No | Partial | — | [60] | | Fetal-hNSCs | Rats/mice, contusion/avulsion | Yes | Yes | — | [61–63] | | Spinal cord-hNPCs | Rats, T8, compression | Yes | — | — | [64] | | Fetal-hNPCs-OPCs | Rats, T8, compression | Yes | Yes | — | [50] | | Fetal-hNSCs-Olig2 | Rats, T9-10, contusion | Yes | Yes | — | [65] | | Fetal-rNSCs + OECs | Rats, T8, compression | Yes | Yes | — | [66] | | rNSCs-TrkC + NT-3 | Rats, T10, transection | Yes | Yes | — | [67] |
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Oligodendrocyte progenitor cells (OPCs); olfactory ensheathing cells (OECs).
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