Stem Cells International / 2015 / Article / Tab 1

Review Article

MicroRNA Regulation of Brain Tumour Initiating Cells in Central Nervous System Tumours

Table 1

miRNAs regulating BTICs in gliomas and GBM stem cells.

MicroRNAsTargetsExpression in GSCsReference

Adult patients
miR-128RTKs, EGFR, PDGFR, Akt, Bmi1, HIF-1, VEGF, E2F3Downregulated [54, 5962]
miR-181a, b, cBcl-2, Downregulated [54, 184]
miR-125bCDK6, CDC25A, E2F2, MMP-2, MMP-9, RECK, TIMP3Downregulated [5658]
miR-143N-RAS, PI3K/Akt, MAPK/ERK Downregulated[57, 63, 185]
miR-153Bcl-2, Mcl-1Downregulated[64, 186]
miR-7EGFR, AktDownregulated[65]
miR-34aAkt, Wnt pathway, c-Met, Notch-1, Notch-2Downregulated[66, 67, 69]
miR-34c-3p, 5pNotch-2Downregulated[70]
miR-326Notch-1, Notch-2, PKM2Downregulated[73]
miR-107Notch-2, MMP-12Downregulated[72]
miR-124SNAI2, CDK6Downregulated[17, 77, 78]
miR-137RTVP-1, c-KIT, YBX1, Akt2, CDC42, CDK6, TGF2Downregulated[77, 79, 80]
miR-451PI3K/Akt pathwayDownregulated[81, 82]
miR-200 familyCREB1, RAB family, SIM2-sDownregulated[8386]
miR-221, miR-222p27 and p57Upregulated[54, 187]
miR-21FASLG, FOXO1, IGFBP3, FBXO11Upregulated[55, 188191]
miR-10 familyCUB, SUSHIUpregulated[87, 88]
miR-17-92 clusterCTGF, PTENUpregulated[91, 92]
miR-582-5pCaspase3, caspase9, BimUpregulated[94]
miR-363Caspase3, caspase9, BimUpregulated[94]

Pediatric patients
miR-25 P57Upregulated[99, 192]
miR-17-92 PTEN, RB1Upregulated[92]

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