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Stem Cells International
Volume 2015, Article ID 148064, 7 pages
Review Article

Hematopoietic Stem and Immune Cells in Chronic HIV Infection

Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA

Received 6 March 2015; Revised 15 July 2015; Accepted 21 July 2015

Academic Editor: Laura Lasagni

Copyright © 2015 Jielin Zhang and Clyde Crumpacker. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hematopoietic stem cell (HSC) belongs to multipotent adult somatic stem cells. A single HSC can reconstitute the entire blood system via self-renewal, differentiation into all lineages of blood cells, and replenishment of cells lost due to attrition or disease in a person’s lifetime. Although all blood and immune cells derive from HSC, immune cells, specifically immune memory cells, have the properties of HSC on self-renewal and differentiation into lineage effector cells responding to the invading pathogens. Moreover, the interplay between immune memory cell and viral pathogen determines the course of a viral infection. Here, we state our point of view on the role of blood stem and progenitor cell in chronic HIV infection, with a focus on memory CD4 T-cell in the context of HIV/AIDS eradication and cure.