Bcl-xL Genetic Modification Enhanced the Therapeutic Efficacy of Mesenchymal Stem Cell Transplantation in the Treatment of Heart Infarction

Figure 4

Upregulation of angiogenic cytokines in hBcl-xL-MSCs. ((a)–(c)) Evaluation of the paracrine secretion of VEGF (a), IGF-1 (b), and PDGF (c) by wild type MSCs (pale grey bar), vector-MSCs (dark grey bar), and hBcl-xL-MSCs (black bar). Cells were cultured under either normoxic or hypoxic conditions for 24 hours and the conditioned medium was collected for ELISA. Concentration values are mean ± SD (, ). VEGF: vascular endothelial growth factor; IGF-1: insulin-like growth factor-1; PDGF: plate-derived growth factor.

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