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Stem Cells International
Volume 2015, Article ID 194894, 10 pages
http://dx.doi.org/10.1155/2015/194894
Review Article

The Role of MicroRNAs in Cardiac Stem Cells

Department of Physiology-Heart Otago, Otago School of Medical Sciences, University of Otago, Dunedin 9010, New Zealand

Received 25 October 2014; Revised 14 December 2014; Accepted 5 January 2015

Academic Editor: Joost P. G. Sluijter

Copyright © 2015 Nima Purvis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. A. McCulloch and J. E. Till, “Perspectives on the properties of stem cells,” Nature Medicine, vol. 11, no. 10, pp. 1026–1028, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. R. Katare, A. Oikawa, D. Cesselli et al., “Boosting the pentose phosphate pathway restores cardiac progenitor cell availability in diabetes,” Cardiovascular Research, vol. 97, no. 1, pp. 55–65, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Amadesi, C. Reni, R. Katare et al., “Role for substance P-based nociceptive signaling in progenitor cell activation and angiogenesis during ischemia in mice and in human subjects,” Circulation, vol. 125, no. 14, pp. 1774–1786, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Katare, F. Riu, K. Mitchell et al., “Transplantation of human pericyte progenitor cells improves the repair of infarcted heart through activation of an angiogenic program involving micro-RNA-132,” Circulation Research, vol. 109, no. 8, pp. 894–906, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. R. Bolli, X.-L. Tang, S. K. Sanganalmath et al., “Intracoronary delivery of autologous cardiac stem cells improves cardiac function in a porcine model of chronic ischemic cardiomyopathy,” Circulation, vol. 128, no. 2, pp. 122–131, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. A. R. Williams, K. E. Hatzistergos, B. Addicott et al., “Enhanced effect of combining human cardiac stem cells and bone marrow mesenchymal stem cells to reduce infarct size and to restore cardiac function after myocardial infarction,” Circulation, vol. 127, no. 2, pp. 213–223, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. F. G. P. Welt, R. Gallegos, J. Connell et al., “Effect of cardiac stem cells on left-ventricular remodeling in a canine model of chronic myocardial infarction,” Circulation: Heart Failure, vol. 6, no. 1, pp. 99–106, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Leri, “Human cardiac stem cells: the heart of a truth,” Circulation, vol. 120, no. 25, pp. 2515–2518, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Katare, A. Caporali, C. Emanueli, and P. Madeddu, “Benfotiamine improves functional recovery of the infarcted heart via activation of pro-survival G6PD/Akt signaling pathway and modulation of neurohormonal response,” Journal of Molecular and Cellular Cardiology, vol. 49, no. 4, pp. 625–638, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Katare, A. Caporali, L. Zentilin et al., “Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling,” Circulation Research, vol. 108, no. 10, pp. 1238–1251, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. R. G. Katare, A. Caporali, A. Oikawa, M. Meloni, C. Emanuel, and P. Madeddu, “Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway,” Circulation: Heart Failure, vol. 3, no. 2, pp. 294–305, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. K. Urbanek, D. Torella, F. Sheikh et al., “Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 24, pp. 8692–8697, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. N. Smart, K. N. Dubé, and P. R. Riley, “Epicardial progenitor cells in cardiac regeneration and neovascularisation,” Vascular Pharmacology, vol. 58, no. 3, pp. 164–173, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Linke, P. Müller, D. Nurzynska et al., “Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 25, pp. 8966–8971, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. A. P. Beltrami, L. Barlucchi, D. Torella et al., “Adult cardiac stem cells are multipotent and support myocardial regeneration,” Cell, vol. 114, no. 6, pp. 763–776, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Scobioala, R. Klocke, M. Kuhlmann et al., “Up-regulation of nestin in the infarcted myocardium potentially indicates differentiation of resident cardiac stem cells into various lineages including cardiomyocytes,” The FASEB Journal, vol. 22, no. 4, pp. 1021–1031, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. M.-J. Goumans, T. P. de Boer, A. M. Smits et al., “TGF-β1 induces efficient differentiation of human cardiomyocyte progenitor cells into functional cardiomyocytes in vitro,” Stem Cell Research, vol. 1, no. 2, pp. 138–149, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. P. Anversa, J. Kajstura, A. Leri, and R. Bolli, “Life and death of cardiac stem cells: a paradigm shift in cardiac biology,” Circulation, vol. 113, no. 11, pp. 1451–1463, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. K. A. Jackson, S. M. Majka, H. Wang et al., “Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells,” Journal of Clinical Investigation, vol. 107, no. 11, pp. 1395–1402, 2001. View at Publisher · View at Google Scholar · View at Scopus
  20. B. Dawn, A. B. Stein, K. Urbanek et al., “Cardiac stem cells delivered intravascularly traverse the vessel barrier, regenerate infarcted myocardium, and improve cardiac function,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 10, pp. 3766–3771, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. B. Nadal-Ginard, G. M. Ellison, and D. Torella, “The cardiac stem cell compartment is indispensable for myocardial cell homeostasis, repair and regeneration in the adult,” Stem Cell Research, vol. 13, pp. 615–630, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. F. Quaini, K. Urbanek, A. P. Beltrami et al., “Chimerism of the transplanted heart,” The New England Journal of Medicine, vol. 346, no. 1, pp. 5–15, 2002. View at Publisher · View at Google Scholar · View at Scopus
  23. A. M. Smits, P. van Vliet, C. H. Metz et al., “Human cardiomyocyte progenitor cells differentiate into functional mature cardiomyocytes: an in vitro model for studying human cardiac physiology and pathophysiology,” Nature Protocols, vol. 4, no. 2, pp. 232–243, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. E. Messina, L. De Angelis, G. Frati et al., “Isolation and expansion of adult cardiac stem cells from human and murine heart,” Circulation Research, vol. 95, no. 9, pp. 911–921, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. M. E. Rawles, “The heart-forming areas of the early chick blastoderm,” Physiological Zoology, vol. 16, no. 1, pp. 22–43, 1943. View at Google Scholar
  26. C. Bearzi, M. Rota, T. Hosoda et al., “Human cardiac stem cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 35, pp. 14068–14073, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. R. M. Seaberg and D. van der Kooy, “Stem and progenitor cells: the premature desertion of rigorous definitions,” Trends in Neurosciences, vol. 26, no. 3, pp. 125–131, 2003. View at Publisher · View at Google Scholar · View at Scopus
  28. K. Matsuura, T. Nagai, N. Nishigaki et al., “Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes,” Journal of Biological Chemistry, vol. 279, pp. 11384–11391, 2014. View at Google Scholar
  29. H. Oh, S. B. Bradfute, T. D. Gallardo et al., “Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 21, pp. 12313–12318, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Valente, D. S. Nascimento, A. Cumano, and P.-d.-Ó. Perpétua, “Pinto-do OP: Sca-1+ cardiac progenitor cells and heart-making: a critical synopsis,” Stem Cells and Development, vol. 23, no. 19, pp. 2263–2273, 2014. View at Publisher · View at Google Scholar
  31. S. Ryzhov, A. E. Goldstein, S. V. Novitskiy, M. R. Blackburn, I. Biaggioni, and I. Feoktistov, “Role of A 2B adenosine receptors in regulation of paracrine functions of stem cell antigen 1-positive cardiac stromal cells,” Journal of Pharmacology and Experimental Therapeutics, vol. 341, no. 3, pp. 764–774, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. D. Dey, L. Han, M. Bauer et al., “Dissecting the molecular relationship among various cardiogenic progenitor cells,” Circulation Research, vol. 112, no. 9, pp. 1253–1262, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. G. M. Ellison, C. Vicinanza, A. J. Smith et al., “Adult c-kitpos cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair,” Cell, vol. 154, no. 4, pp. 827–842, 2013. View at Publisher · View at Google Scholar · View at Scopus
  34. J. Q. He, D. M. Vu, G. Hunt, A. Chugh, A. Bhatnagar, and R. Bolli, “Human cardiac stem cells isolated from atrial appendages stably express c-kit,” PLoS ONE, vol. 6, no. 11, Article ID e27719, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. S. H. Choi, S. Y. Jung, W. Suh, S. H. Baek, and S.-M. Kwon, “Establishment of isolation and expansion protocols for human cardiac C-kit-positive progenitor cells for stem cell therapy,” Transplantation Proceedings, vol. 45, no. 1, pp. 420–426, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. T. Hosoda, “C-kit-positive cardiac stem cells and myocardial regeneration,” American Journal of Cardiovascular Disease, vol. 2, pp. 58–67, 2012. View at Google Scholar
  37. A. R. Chugh, G. M. Beache, J. H. Loughran et al., “Administration of cardiac stem cells in patients with ischemic cardiomyopathy: the SCIPIO trial: surgical aspects and interim analysis of myocardial function and viability by magnetic resonance,” Circulation, vol. 126, no. 11, pp. S54–S64, 2012. View at Publisher · View at Google Scholar · View at Scopus
  38. J. H. van Berlo, O. Kanisicak, M. Maillet et al., “c-Kit+ cells minimally contribute cardiomyocytes to the heart,” Nature, vol. 509, no. 7500, pp. 337–341, 2014. View at Publisher · View at Google Scholar · View at Scopus
  39. P. Pandur, I. O. Sirbu, S. J. Kühl, M. Philipp, and M. Kühl, “Islet1-expressing cardiac progenitor cells: a comparison across species,” Development Genes and Evolution, vol. 223, no. 1-2, pp. 117–129, 2013. View at Publisher · View at Google Scholar · View at Scopus
  40. A. Barzelay, E. Hochhauser, M. Entin-Meer et al., “Islet-1 gene delivery improves myocardial performance after experimental infarction,” Atherosclerosis, vol. 223, no. 2, pp. 284–290, 2012. View at Publisher · View at Google Scholar · View at Scopus
  41. L. Bu, X. Jiang, S. Martin-Puig et al., “Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages,” Nature, vol. 460, no. 7251, pp. 113–117, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. R. Bolli, A. R. Chugh, D. D'Amario et al., “Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial,” The Lancet, vol. 378, no. 9806, pp. 1847–1857, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. R. R. Makkar, R. R. Smith, K. Cheng et al., “Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial,” The Lancet, vol. 379, no. 9819, pp. 895–904, 2012. View at Publisher · View at Google Scholar · View at Scopus
  44. S. A. J. Chamuleau, K. R. Vrijsen, D. G. Rokosh, X. L. Tang, J. J. Piek, and R. Bolli, “Cell therapy for ischaemic heart disease: focus on the role of resident cardiac stem cells,” Netherlands Heart Journal, vol. 17, no. 5, pp. 199–207, 2009. View at Publisher · View at Google Scholar · View at Scopus
  45. K. U. Hong, Y. Guo, Q. H. Li et al., “c-kit+ cardiac stem cells alleviate post-myocardial infarction left ventricular dysfunction despite poor engraftment and negligible retention in the recipient heart,” PLoS ONE, vol. 9, no. 5, Article ID e96725, 2014. View at Publisher · View at Google Scholar · View at Scopus
  46. K. G. Oldroyd, C. Berry, and J. Bartunek, “Myocardial repair and regeneration: bone marrow or cardiac stem cells?” Molecular Therapy, vol. 20, no. 6, pp. 1102–1105, 2012. View at Publisher · View at Google Scholar · View at Scopus
  47. F. Mouquet, O. Pfister, M. Jain et al., “Restoration of cardiac progenitor cells after myocardial infarction by self-proliferation and selective homing of bone marrow-derived stem cells,” Circulation Research, vol. 97, no. 11, pp. 1090–1092, 2005. View at Publisher · View at Google Scholar · View at Scopus
  48. S. X. Liang and W. D. Phillips, “Migration of resident cardiac stem cells in myocardial infarction,” Anatomical Record, vol. 296, no. 2, pp. 184–191, 2013. View at Publisher · View at Google Scholar · View at Scopus
  49. R. G. Katare and P. Madeddu, “Pericytes from human veins for treatment of myocardial ischemia,” Trends in Cardiovascular Medicine, vol. 23, no. 3, pp. 66–70, 2013. View at Publisher · View at Google Scholar · View at Scopus
  50. M. Gnecchi, Z. Zhang, A. Ni, and V. J. Dzau, “Paracrine mechanisms in adult stem cell signaling and therapy,” Circulation Research, vol. 103, no. 11, pp. 1204–1219, 2008. View at Publisher · View at Google Scholar · View at Scopus
  51. M. Gnecchi, H. He, O. D. Liang et al., “Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells,” Nature Medicine, vol. 11, no. 4, pp. 367–368, 2005. View at Publisher · View at Google Scholar · View at Scopus
  52. L. Timmers, S. K. Lim, F. Arslan et al., “Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium,” Stem Cell Research, vol. 1, no. 2, pp. 129–137, 2008. View at Publisher · View at Google Scholar · View at Scopus
  53. J. P. G. Sluijter, V. Verhage, J. C. Deddens, F. Van Den Akker, and P. A. Doevendans, “Microvesicles and exosomes for intracardiac communication,” Cardiovascular Research, vol. 102, no. 2, pp. 302–311, 2014. View at Publisher · View at Google Scholar · View at Scopus
  54. S. Windmolders, A. De Boeck, R. Koninckx et al., “Mesenchymal stem cell secreted platelet derived growth factor exerts a pro-migratory effect on resident Cardiac Atrial appendage Stem Cells,” Journal of Molecular and Cellular Cardiology, vol. 66, pp. 177–188, 2014. View at Publisher · View at Google Scholar · View at Scopus
  55. C. Huang, H. Gu, Q. Yu, M. C. Manukyan, J. A. Poynter, and M. Wang, “Sca-1+ cardiac stem cells mediate acute cardioprotection via paracrine factor SDF-1 following myocardial ischemia/reperfusion,” PLoS ONE, vol. 6, no. 12, Article ID e29246, 2011. View at Publisher · View at Google Scholar · View at Scopus
  56. L. Chen, Y. Wang, Y. Pan et al., “Cardiac progenitor-derived exosomes protect ischemic myocardium from acute ischemia/reperfusion injury,” Biochemical and Biophysical Research Communications, vol. 431, no. 3, pp. 566–571, 2013. View at Publisher · View at Google Scholar · View at Scopus
  57. V. K. Gangaraju and H. Lin, “MicroRNAs: key regulators of stem cells,” Nature Reviews Molecular Cell Biology, vol. 10, no. 2, pp. 116–125, 2009. View at Publisher · View at Google Scholar · View at Scopus
  58. K. N. Ivey, A. Muth, J. Arnold et al., “MicroRNA regulation of cell lineages in mouse and human embryonic stem cells,” Cell Stem Cell, vol. 2, no. 3, pp. 219–229, 2008. View at Publisher · View at Google Scholar · View at Scopus
  59. M. Count, 2013, http://www.mirbase.org/.
  60. R. C. Friedman, K. K.-H. Farh, C. B. Burge, and D. P. Bartel, “Most mammalian mRNAs are conserved targets of microRNAs,” Genome Research, vol. 19, no. 1, pp. 92–105, 2009. View at Publisher · View at Google Scholar · View at Scopus
  61. S. Rawal, P. Manning, and R. Katare, “Cardiovascular microRNAs: as modulators and diagnostic biomarkers of diabetic heart disease,” Cardiovascular Diabetology, vol. 13, no. 1, article 44, 2014. View at Publisher · View at Google Scholar · View at Scopus
  62. J. Han, Y. Lee, K.-H. Yeom et al., “Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex,” Cell, vol. 125, no. 5, pp. 887–901, 2006. View at Publisher · View at Google Scholar · View at Scopus
  63. J. G. Ruby, C. H. Jan, and D. P. Bartel, “Intronic microRNA precursors that bypass Drosha processing,” Nature, vol. 448, no. 7149, pp. 83–86, 2007. View at Publisher · View at Google Scholar · View at Scopus
  64. J. Winter, S. Jung, S. Keller, R. I. Gregory, and S. Diederichs, “Many roads to maturity: MicroRNA biogenesis pathways and their regulation,” Nature Cell Biology, vol. 11, no. 3, pp. 228–234, 2009. View at Publisher · View at Google Scholar · View at Scopus
  65. T. Takaya, K. Ono, T. Kawamura et al., “MicroRNA-1 and microRNA-133 in spontaneous myocardial differentiation of mouse embryonic stem cells,” Circulation Journal, vol. 73, no. 8, pp. 1492–1497, 2009. View at Publisher · View at Google Scholar · View at Scopus
  66. Y. Zhao, E. Samal, and D. Srivastava, “Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis,” Nature, vol. 436, no. 7048, pp. 214–220, 2005. View at Publisher · View at Google Scholar · View at Scopus
  67. A. Carè, D. Catalucci, F. Felicetti et al., “MicroRNA-133 controls cardiac hypertrophy,” Nature Medicine, vol. 13, no. 5, pp. 613–618, 2007. View at Publisher · View at Google Scholar · View at Scopus
  68. J. P. G. Sluijter, A. van Mil, P. van Vliet et al., “MicroRNA-1 and -499 regulate differentiation and proliferation in human-derived cardiomyocyte progenitor cells,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 30, no. 4, pp. 859–868, 2010. View at Publisher · View at Google Scholar · View at Scopus
  69. C. Kwon, Z. Han, E. N. Olson, and D. Srivastava, “MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 52, pp. 18986–18991, 2005. View at Publisher · View at Google Scholar · View at Scopus
  70. M. Nemir, A. Croquelois, T. Pedrazzini, and F. Radtke, “Induction of cardiogenesis in embryonic stem cells via downregulation of Notch1 signaling,” Circulation Research, vol. 98, no. 12, pp. 1471–1478, 2006. View at Publisher · View at Google Scholar · View at Scopus
  71. J. Xiao, D. Liang, H. Zhang et al., “MicroRNA-204 is required for differentiation of human-derived cardiomyocyte progenitor cells,” Journal of Molecular and Cellular Cardiology, vol. 53, no. 6, pp. 751–759, 2012. View at Publisher · View at Google Scholar · View at Scopus
  72. S. Crippa, M. Cassano, G. Messina et al., “miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors,” The Journal of Cell Biology, vol. 193, no. 7, pp. 1197–1212, 2011. View at Publisher · View at Google Scholar · View at Scopus
  73. Y.-K. Kim, J. Yu, T. S. Han et al., “Functional links between clustered microRNAs: suppression of cell-cycle inhibitors by microRNA clusters in gastric cancer,” Nucleic Acids Research, vol. 37, no. 5, pp. 1672–1681, 2009. View at Publisher · View at Google Scholar · View at Scopus
  74. P. Sirish, J. E. Lopez, N. Li et al., “MicroRNA profiling predicts a variance in the proliferative potential of cardiac progenitor cells derived from neonatal and adult murine hearts,” Journal of Molecular and Cellular Cardiology, vol. 52, no. 1, pp. 264–272, 2012. View at Publisher · View at Google Scholar · View at Scopus
  75. J. Wang, S. B. Greene, M. Bonilla-Claudio et al., “Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism,” Developmental Cell, vol. 19, no. 6, pp. 903–912, 2010. View at Publisher · View at Google Scholar · View at Scopus
  76. A. Frustaci, J. Kajstura, C. Chimenti et al., “Myocardial cell death in human diabetes,” Circulation Research, vol. 87, no. 12, pp. 1123–1132, 2000. View at Publisher · View at Google Scholar · View at Scopus
  77. A. van Mil, K. R. Vrijsen, M.-J. Goumans, C. H. Metz, P. A. Doevendans, and J. P. Sluijter, “MicroRNA-1 enhances the angiogenic differentiation of human cardiomyocyte progenitor cells,” Journal of Molecular Medicine, vol. 91, no. 8, pp. 1001–1012, 2013. View at Publisher · View at Google Scholar · View at Scopus
  78. S. Anand, B. K. Majeti, L. M. Acevedo et al., “MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis,” Nature Medicine, vol. 16, no. 8, pp. 909–914, 2010. View at Publisher · View at Google Scholar · View at Scopus
  79. S. Anand, “A brief primer on microRNAs and their roles in angiogenesis,” Vascular Cell, vol. 5, no. 1, article 2, 2013. View at Publisher · View at Google Scholar · View at Scopus
  80. G. H. Gibbons and V. J. Dzau, “The emerging concept of vascular remodeling,” The New England Journal of Medicine, vol. 330, no. 20, pp. 1431–1438, 1994. View at Publisher · View at Google Scholar · View at Scopus
  81. S. Albinsson, Y. Suarez, A. Skoura, S. Offermanns, J. M. Miano, and W. C. Sessa, “MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 30, no. 6, pp. 1118–1126, 2010. View at Publisher · View at Google Scholar · View at Scopus
  82. C. Urbich, A. Kuehbacher, and S. Dimmeler, “Role of microRNAs in vascular diseases, inflammation, and angiogenesis,” Cardiovascular Research, vol. 79, no. 4, pp. 581–588, 2008. View at Publisher · View at Google Scholar · View at Scopus
  83. N. Felli, L. Fontana, E. Pelosi et al., “MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 50, pp. 18081–18086, 2005. View at Publisher · View at Google Scholar · View at Scopus
  84. A. Aicher, C. Heeschen, C. Mildner-Rihm et al., “Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells,” Nature Medicine, vol. 9, no. 11, pp. 1370–1376, 2003. View at Publisher · View at Google Scholar · View at Scopus
  85. Y. Li, Y.-H. Song, F. Li, T. Yang, Y. W. Lu, and Y.-J. Geng, “microRNA-221 regulates high glucose-induced endothelial dysfunction,” Biochemical and Biophysical Research Communications, vol. 381, no. 1, pp. 81–83, 2009. View at Publisher · View at Google Scholar · View at Scopus
  86. B. M. Herrera, H. E. Lockstone, J. M. Taylor et al., “Global microRNA expression profiles in insulin target tissues in a spontaneous rat model of type 2 diabetes,” Diabetologia, vol. 53, no. 6, pp. 1099–1109, 2010. View at Publisher · View at Google Scholar · View at Scopus
  87. S. Hu, M. Huang, P. K. Nguyen et al., “Novel microRNA prosurvival cocktail for improving engraftment and function of cardiac progenitor cell transplantation,” Circulation, vol. 124, pp. S27–S34, 2011. View at Publisher · View at Google Scholar · View at Scopus
  88. S. Roush and F. J. Slack, “The let-7 family of microRNAs,” Trends in Cell Biology, vol. 18, no. 10, pp. 505–516, 2008. View at Publisher · View at Google Scholar · View at Scopus
  89. J. Liu, A. van Mil, K. Vrijsen et al., “MicroRNA-155 prevents necrotic cell death in human cardiomyocyte progenitor cells via targeting RIP1,” Journal of Cellular and Molecular Medicine, vol. 15, no. 7, pp. 1474–1482, 2011. View at Publisher · View at Google Scholar · View at Scopus
  90. A. Moore, A. Shindikar, I. Fomison-Nurse et al., “Rapid onset of cardiomyopathy in STZ-induced female diabetic mice involves the downregulation of pro-survival Pim-1,” Cardiovascular Diabetology, vol. 13, article 68, 2014. View at Publisher · View at Google Scholar
  91. Y. Li, C.-M. Yang, Y. Xi et al., “MicroRNA-1/133 targeted dysfunction of potassium channels KCNE1 and KCNQ1 in human cardiac progenitor cells with simulated hyperglycemia,” International Journal of Cardiology, vol. 167, no. 3, pp. 1076–1078, 2013. View at Publisher · View at Google Scholar · View at Scopus
  92. B. Yang, H. Lin, J. Xiao et al., “The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2,” Nature Medicine, vol. 13, no. 4, pp. 486–491, 2007. View at Publisher · View at Google Scholar · View at Scopus
  93. X. Shi-Wen, A. Leask, and D. Abraham, “Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis,” Cytokine and Growth Factor Reviews, vol. 19, no. 2, pp. 133–144, 2008. View at Publisher · View at Google Scholar · View at Scopus
  94. M. S. Ahmed, J. Gravning, V. N. Martinov et al., “Mechanisms of novel cardioprotective functions of CCN2/CTGF in myocardial ischemia-reperfusion injury,” The American Journal of Physiology—Heart and Circulatory Physiology, vol. 300, no. 4, pp. H1291–H1302, 2011. View at Publisher · View at Google Scholar · View at Scopus
  95. A. M. Babic, C. C. Chen, and L. F. Lau, “Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo,” Molecular and Cellular Biology, vol. 19, pp. 2958–2966, 1999. View at Google Scholar
  96. S. W. Kim, H. W. Kim, W. Huang et al., “Cardiac stem cells with electrical stimulation improve ischaemic heart function through regulation of connective tissue growth factor and miR-378,” Cardiovascular Research, vol. 100, no. 2, pp. 241–251, 2013. View at Publisher · View at Google Scholar · View at Scopus
  97. T. Hosoda, H. Zheng, M. Cabral-Da-Silva et al., “Human cardiac stem cell differentiation is regulated by a mircrine mechanism,” Circulation, vol. 123, no. 12, pp. 1287–1296, 2011. View at Publisher · View at Google Scholar · View at Scopus
  98. A. Izarra, I. Moscoso, E. Levent et al., “miR-133a enhances the protective capacity of cardiac progenitors cells after myocardial infarction,” Stem Cell Reports, vol. 3, no. 6, pp. 1029–1042, 2014. View at Publisher · View at Google Scholar