Research Article

Osteopontin Overexpression Induced Tumor Progression and Chemoresistance to Oxaliplatin through Induction of Stem-Like Properties in Human Colorectal Cancer

Table 1

Clinicopathological correlation of OPN overexpression in CRC ().

Clinicopathological featuresCategory Number of casesOPN overexpression
(ΔΔCt) (mean ± SEM)
value

Age<65
65
34
50
−0.613 ± 0.475
−0.767 ± 0.371
0.798

GenderMale
Female
59
25
−0.542 ± 0.335
−1.089 ± 0.581
0.394

Tumor size<5 cm
5 cm
49
35
−0.824 ± 0.412
−0.537 ± 0.400
0.630

Histological gradeWell/moderate
Poor/undifferentiated
75
9
0.599 ± 0.309
−3.024 ± 1.472
0.020

Lymph node metastasisAbsent
Present
37
47
−0.081 ± 0.422
−1.196 ± 0.390
0.057

Tumor AJCC stageI to II
III to IV
31
53
0.219 ± 0.474
−1.245 ± 0.352
0.014

Distant metastasisAbsent
Present
64
20
−0.427 ± 0.338
−1.594 ± 0.537
0.088