Table of Contents Author Guidelines Submit a Manuscript
Stem Cells International
Volume 2015 (2015), Article ID 412467, 12 pages
http://dx.doi.org/10.1155/2015/412467
Research Article

Analysis of the Pro- and Anti-Inflammatory Cytokines Secreted by Adult Stem Cells during Differentiation

1Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
2Departments of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
3Departments of Surgery, Tulane University School of Medicine, New Orleans, LA 70112, USA
4Departments of Pharmacology, Tulane University School of Medicine, New Orleans, LA 70112, USA

Received 10 November 2014; Revised 12 December 2014; Accepted 15 December 2014

Academic Editor: Norio Motohashi

Copyright © 2015 Amy L. Strong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Vallée, J.-F. Côté, and J. Fradette, “Adipose-tissue engineering: taking advantage of the properties of human adipose-derived stem/stromal cells,” Pathologie Biologie, vol. 57, no. 4, pp. 309–317, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Vermette, V. Trottier, V. Ménard, L. Saint-Pierre, A. Roy, and J. Fradette, “Production of a new tissue-engineered adipose substitute from human adipose-derived stromal cells,” Biomaterials, vol. 28, no. 18, pp. 2850–2860, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. B. A. Bunnell, M. Flaat, C. Gagliardi, B. Patel, and C. Ripoll, “Adipose-derived stem cells: isolation, expansion and differentiation,” Methods, vol. 45, no. 2, pp. 115–120, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. J. M. Gimble, A. J. Katz, and B. A. Bunnell, “Adipose-derived stem cells for regenerative medicine,” Circulation Research, vol. 100, no. 9, pp. 1249–1260, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. T. Komori, “Regulation of osteoblast differentiation by transcription factors,” Journal of Cellular Biochemistry, vol. 99, no. 5, pp. 1233–1239, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Pratap, J. J. Wixted, T. Gaur et al., “Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells,” Cancer Research, vol. 68, no. 19, pp. 7795–7802, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Lee, D. Gupta, N. J. Panetta et al., “Elucidating mechanisms of osteogenesis in human adipose-derived stromal cells via microarray analysis,” Journal of Craniofacial Surgery, vol. 21, no. 4, pp. 1136–1141, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. S. R. Farmer, “Transcriptional control of adipocyte formation,” Cell Metabolism, vol. 4, no. 4, pp. 263–273, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. P. A. Zuk, M. Zhu, P. Ashjian et al., “Human adipose tissue is a source of multipotent stem cells,” Molecular Biology of the Cell, vol. 13, no. 12, pp. 4279–4295, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. A.-M. Rodriguez, C. Elabd, E.-Z. Amri, G. Ailhaud, and C. Dani, “The human adipose tissue is a source of multipotent stem cells,” Biochimie, vol. 87, no. 1, pp. 125–128, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. K. Hess, A. Ushmorov, J. Fiedler, R. E. Brenner, and T. Wirth, “TNFα promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF-κB signaling pathway,” Bone, vol. 45, no. 2, pp. 367–376, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. B. Osta, F. Lavocat, A. Eljaafari, and P. Miossec, “Effects of interleukin-17A on osteogenic differentiation of isolated human mesenchymal stem cells,” Frontiers in Immunology, vol. 5, p. 425, 2014. View at Publisher · View at Google Scholar
  13. K. Sonomoto, K. Yamaoka, K. Oshita et al., “Interleukin-1β induces differentiation of human mesenchymal stem cells into osteoblasts via the wnt-5a/receptor tyrosine kinase-like orphan receptor 2 pathway,” Arthritis & Rheumatism, vol. 64, no. 10, pp. 3355–3363, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. E. Ferreira, R. M. Porter, N. Wehling et al., “Inflammatory cytokines induce a unique mineralizing phenotype in mesenchymal stem cells derived from human bone marrow,” Journal of Biological Chemistry, vol. 288, no. 41, pp. 29494–29505, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. G. R. Mundy, “Osteoporosis and inflammation,” Nutrition Reviews, vol. 65, no. 12, pp. S147–S151, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Neve, A. Corrado, and F. P. Cantatore, “Osteoblast physiology in normal and pathological conditions,” Cell and Tissue Research, vol. 343, no. 2, pp. 289–302, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. J.-S. Shao, S.-L. Cheng, J. Sadhu, and D. A. Towler, “Inflammation and the osteogenic regulation of vascular calcification: a review and perspective,” Hypertension, vol. 55, no. 3, pp. 579–592, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. J. A. Forsberg, B. K. Potter, E. M. Polfer, S. D. Safford, and E. A. Elster, “Do inflammatory markers portend heterotopic ossification and wound failure in combat wounds?” Clinical Orthopaedics and Related Research, vol. 472, pp. 2845–2854, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. J. R. Peterson, S. de la Rosa, O. Eboda et al., “Treatment of heterotopic ossification through remote ATP hydrolysis,” Science Translational Medicine, vol. 6, no. 255, p. 255ra132, 2014. View at Publisher · View at Google Scholar
  20. M. Suzawa, I. Takada, J. Yanagisawa et al., “Cytokines suppress adipogenesis and PPAR-γ function through the TAK1/TAB1/NIK cascade,” Nature Cell Biology, vol. 5, no. 3, pp. 224–230, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. P. Trayhurn, “Hypoxia and adipose tissue function and dysfunction in obesity,” Physiological Reviews, vol. 93, no. 1, pp. 1–21, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Iyer, D. P. Fairlie, J. B. Prins, B. D. Hammock, and L. Brown, “Inflammatory lipid mediators in adipocyte function and obesity,” Nature Reviews Endocrinology, vol. 6, no. 2, pp. 71–82, 2010. View at Publisher · View at Google Scholar · View at Scopus