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Stem Cells International
Volume 2015, Article ID 438026, 14 pages
Review Article

Use of Adult Stem Cells for Cartilage Tissue Engineering: Current Status and Future Developments

1Normandie Université, 14032 Caen, France
2UNICAEN, EA4652 MILPAT, 14032 Caen, France

Received 30 September 2014; Revised 16 March 2015; Accepted 17 March 2015

Academic Editor: Abhijit De

Copyright © 2015 Catherine Baugé and Karim Boumédiene. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Due to their low self-repair ability, cartilage defects that result from joint injury, aging, or osteoarthritis, are the most often irreversible and are a major cause of joint pain and chronic disability. So, in recent years, researchers and surgeons have been working hard to elaborate cartilage repair interventions for patients who suffer from cartilage damage. However, current methods do not perfectly restore hyaline cartilage and may lead to the apparition of fibro- or hypertrophic cartilage. In the next years, the development of new strategies using adult stem cells, in scaffolds, with supplementation of culture medium and/or culture in low oxygen tension should improve the quality of neoformed cartilage. Through these solutions, some of the latest technologies start to bring very promising results in repairing cartilage from traumatic injury or chondropathies. This review discusses the current knowledge about the use of adult stem cells in the context of cartilage tissue engineering and presents clinical trials in progress, as well as in the future, especially in the field of bioprinting stem cells.