Neuroprotective and Antiapoptotic Activity of Lineage-Negative Bone Marrow Cells after Intravitreal Injection in a Mouse Model of Acute Retinal Injury

Figure 6

Global changes in gene expression in murine retinas on the 7th day after NaIO₃-injury. The heat-map represents expression levels of genes representing particular gene ontologies (GOs) with large gene expression changes (fold change > 4) in Lin⁻BMC-treated eyes compared to PBS-injected control eyes. For a given GO, an average value was computed and subtracted from each observation. Each column comprises a set of horizontal lines, with each line representing a particular GO. Gene expression levels comprising a particular GO are indicated on a color scale, with yellow corresponding to the highest level of expression and blue corresponding to the lowest level; the range of expression rate from the analyzed genes is shown below the graph. The GO terms, listed on the left side of the graph (-direction), were selected if the genes annotated with the corresponding GO terms were considered statistically significantly overrepresented.