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Stem Cells International
Volume 2015, Article ID 640218, 11 pages
http://dx.doi.org/10.1155/2015/640218
Research Article

Modulation of Hyaluronan Synthesis by the Interaction between Mesenchymal Stem Cells and Osteoarthritic Chondrocytes

1Hospital Israelita Albert Einstein, No. 627/701, 05652-900 São Paulo, SP, Brazil
2Department of Biochemistry, Molecular Biology Program, Federal University of São Paulo, No. 100, 04044-020 São Paulo, SP, Brazil
3Orthopedic Division, Federal University of São Paulo, No. 783, 04038-031 São Paulo, SP, Brazil

Received 13 November 2014; Revised 11 December 2014; Accepted 2 January 2015

Academic Editor: Mark F. Pittenger

Copyright © 2015 Eliane Antonioli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Maldonado and J. Nam, “The role of changes in extracellular matrix of cartilage in the presence of inflammation on the pathology of osteoarthritis,” BioMed Research International, vol. 2013, Article ID 284873, 10 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. R. F. Loeser, “Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix,” Osteoarthritis and Cartilage, vol. 17, no. 8, pp. 971–979, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Dudhia, “Aggrecan, aging and assembly in articular cartilage,” Cellular and Molecular Life Sciences, vol. 62, no. 19-20, pp. 2241–2256, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Aspberg, “The Different Roles of Aggrecan Interaction Domains,” The Journal of Histochemistry and Cytochemistry, vol. 60, no. 12, pp. 987–996, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. N. Itano and K. Kimata, “Mammalian hyaluronan synthases,” IUBMB Life, vol. 54, no. 4, pp. 195–199, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. P. H. Weigel and P. L. DeAngelis, “Hyaluronan synthases: a decade-plus of novel glycosyltransferases,” Journal of Biological Chemistry, vol. 282, no. 51, pp. 36777–36781, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. K. S. Girish and K. Kemparaju, “The magic glue hyaluronan and its eraser hyaluronidase: a biological overview,” Life Sciences, vol. 80, no. 21, pp. 1921–1943, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. S. B. Nicoll, O. Barak, A. B. Csóka, R. S. Bhatnagar, and R. Stern, “Hyaluronidases and CD44 undergo differential modulation during chondrogenesis,” Biochemical and Biophysical Research Communications, vol. 292, no. 4, pp. 819–825, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Stern and M. J. Jedrzejas, “Hyaluronidases: their genomics, structures, and mechanisms of action,” Chemical Reviews, vol. 106, no. 3, pp. 818–839, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. G. Chow, C. B. Knudson, and W. Knudson, “Expression and cellular localization of human hyaluronidase-2 in articular chondrocytes and cultured cell lines,” Osteoarthritis and Cartilage, vol. 14, no. 9, pp. 849–858, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Yoshida, S. Sai, K. Marumo et al., “Expression analysis of three isoforms of hyaluronan synthase and hyaluronidase in the synovium of knees in osteoarthritis and rheumatoid arthritis by quantitative real-time reverse transcriptase polymerase chain reaction,” Arthritis Research & Therapy., vol. 6, no. 6, pp. R514–R520, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. C. R. Flannery, C. B. Little, C. E. Hughes, and B. Caterson, “Expression and activity of articular cartilage hyaluronidases,” Biochemical and Biophysical Research Communications, vol. 251, no. 3, pp. 824–829, 1998. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Kapoor, J. Martel-Pelletier, D. Lajeunesse, J.-P. Pelletier, and H. Fahmi, “Role of proinflammatory cytokines in the pathophysiology of osteoarthritis,” Nature Reviews Rheumatology, vol. 7, no. 1, pp. 33–42, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. F. Montoya, F. Martínez, M. García-Robles et al., “Clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiation,” Biological Research, vol. 46, no. 4, pp. 441–451, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. A. I. Caplan, “Adult mesenchymal stem cells for tissue engineering versus regenerative medicine,” Journal of Cellular Physiology, vol. 213, no. 2, pp. 341–347, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. A. M. Dimarino, A. I. Caplan, and T. L. Bonfield, “Mesenchymal stem cells in tissue repair,” Frontiers in Immunology, vol. 4, article 201, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. M. B. Murphy, K. Moncivais, and A. I. Caplan, “Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine,” Experimental and Molecular Medicine, vol. 45, no. 11, article e54, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. C. Acharya, A. Adesida, P. Zajac et al., “Enhanced chondrocyte proliferation and mesenchymal stromal cells chondrogenesis in coculture pellets mediate improved cartilage formation,” Journal of Cellular Physiology, vol. 227, no. 1, pp. 88–97, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. J. H. Lai, G. Kajiyama, R. L. Smith, W. Maloney, and F. Yang, “Stem cells catalyze cartilage formation by neonatal articular chondrocytes in 3D biomimetic hydrogels,” Scientific Reports, vol. 3, article 3553, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. M. A. González, E. González-Rey, L. Rico, D. Büscher, and M. Delgado, “Treatment of experimental arthritis by inducing immune tolerance with human adipose-derived mesenchymal stem cells,” Arthritis and Rheumatism, vol. 60, no. 4, pp. 1006–1019, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. J. H. Kellgren and J. S. Lawrence, “Radiological assessment of osteo-arthrosis,” Annals of the Rheumatic Diseases, vol. 16, no. 4, pp. 494–502, 1957. View at Publisher · View at Google Scholar · View at Scopus
  22. F. García-Álvarez, E. Alegre-Aguarón, P. Desportes et al., “Chondrogenic differentiation in femoral bone marrow-derived mesenchymal cells (MSC) from elderly patients suffering osteoarthritis or femoral fracture,” Archives of Gerontology and Geriatrics, vol. 52, no. 2, pp. 239–242, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. J. R. M. Martins, C. C. Passerotti, R. M. B. Maciel, L. O. Sampaio, C. P. Dietrich, and H. B. Nader, “Practical determination of hyaluronan by a new noncompetitive fluorescence-based assay on serum of normal and cirrhotic patients,” Analytical Biochemistry, vol. 319, no. 1, pp. 65–72, 2003. View at Publisher · View at Google Scholar · View at Scopus
  24. L. W. Moreland, “Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action,” Arthritis Research and Therapy, vol. 5, no. 2, pp. 54–67, 2003. View at Google Scholar · View at Scopus
  25. M. Ishijima, T. Nakamura, K. Shimizu et al., “Intra-articular hyaluronic acid injection versus oral non-steroidal anti-inflammatory drug for the treatment of knee osteoarthritis: a multi-center, randomized, open-label, non-inferiority trial,” Arthritis Research and Therapy, vol. 16, no. 1, article R18, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. E. J. Strauss, J. A. Hart, M. D. Miller, R. D. Altman, and J. E. Rosen, “Hyaluronic acid viscosupplementation and osteoarthritis: current uses and future directions,” The American Journal of Sports Medicine, vol. 37, no. 8, pp. 1636–1644, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. C. Manferdini, M. Maumus, E. Gabusi et al., “Adipose-derived mesenchymal stem cells exert antiinflammatory effects on chondrocytes and synoviocytes from osteoarthritis patients through prostaglandin E2,” Arthritis and Rheumatism, vol. 65, no. 5, pp. 1271–1281, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. P. K. Gupta, A. K. Das, A. Chullikana, and A. S. Majumdar, “Mesenchymal stem cells for cartilage repair in osteoarthritis,” Stem Cell Research and Therapy, vol. 3, no. 4, article 25, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. Q. Zuo, W. Cui, F. Liu, Q. Wang, Z. Chen, and W. Fan, “Co-cultivated mesenchymal stem cells support chondrocytic differentiation of articular chondrocytes,” International Orthopaedics, vol. 37, no. 4, pp. 747–752, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. L. Wu, J. C. H. Leijten, N. Georgi, J. N. Post, C. A. Van Blitterswijk, and M. Karperien, “Trophic effects of mesenchymal stem cells increase chondrocyte proliferation and matrix formation,” Tissue Engineering Part A, vol. 17, no. 9-10, pp. 1425–1436, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Aung, G. Gupta, G. Majid, and S. Varghese, “Osteoarthritic chondrocyte-secreted morphogens induce chondrogenic differentiation of human mesenchymal stem cells,” Arthritis and Rheumatism, vol. 63, no. 1, pp. 148–158, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. C. Qu, K. Rilla, R. Tammi, M. Tammi, H. Kröger, and M. J. Lammi, “Extensive CD44-dependent hyaluronan coats on human bone marrow-derived mesenchymal stem cells produced by hyaluronan synthases HAS1, HAS2 and HAS3,” The International Journal of Biochemistry and Cell Biology, vol. 48, no. 1, pp. 45–54, 2014. View at Publisher · View at Google Scholar · View at Scopus
  33. Y. Ono, T. Sakai, H. Hiraiwa et al., “Chondrogenic capacity and alterations in hyaluronan synthesis of cultured human osteoarthritic chondrocytes,” Biochemical and Biophysical Research Communications, vol. 435, no. 4, pp. 733–739, 2013. View at Publisher · View at Google Scholar · View at Scopus
  34. A. D. Recklies, C. White, L. Melching, and P. J. Roughley, “Differential regulation and expression of hyaluronan synthases in human articular chondrocytes, synovial cells and osteosarcoma cells,” The Biochemical Journal, vol. 354, no. 1, pp. 17–24, 2001. View at Publisher · View at Google Scholar · View at Scopus
  35. J. Y. Chung, M. Song, C.-W. Ha, J.-A. Kim, C.-H. Lee, and Y.-B. Park, “Comparison of articular cartilage repair with different hydrogel-human umbilical cord blood-derived mesenchymal stem cell composites in a rat model,” Stem Cell Research and Therapy, vol. 5, no. 2, article 39, 2014. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Sezgin, A. Ç. Demirel, C. Karaca et al., “Does hyaluronan affect inflammatory cytokines in knee osteoarthritis?” Rheumatology International, vol. 25, no. 4, pp. 264–269, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. E. A. Sundman, B. J. Cole, V. Karas et al., “The anti-inflammatory and matrix restorative mechanisms of platelet-rich plasma in osteoarthritis,” The American Journal of Sports Medicine, vol. 42, no. 1, pp. 35–41, 2014. View at Publisher · View at Google Scholar · View at Scopus
  38. M. B. Goldring and M. Otero, “Inflammation in osteoarthritis,” Current Opinion in Rheumatology, vol. 23, no. 5, pp. 471–478, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Leyh, A. Seitz, L. Dürselen et al., “Osteoarthritic cartilage explants affect extracellular matrix production and composition in cocultured bone marrow-derived mesenchymal stem cells and articular chondrocytes,” Stem Cell Research & Therapy, vol. 5, no. 3, article 77, 2014. View at Publisher · View at Google Scholar