Transgenic Strategies to Study Podocyte Loss and Regeneration

Figure 4

Hypothetical scheme of a combinatorial solution for PEC tagging and podocyte-specific ablation. (a) Glomerulus before induction of the two recombinatorial systems (Cre-LoxP and Flp-FRT), which can be induced independently and at different time points. (b) Once induced, the glomerulus would appear with Confetti-tagged PECs and iDTR-expressing podocytes. (c) At the prespecified time and dose, the operator could specifically ablate only podocytes. (d) De novo podocyte generation by the PEC compartment.