Table 1: Major epithelial cell types in adult murine lung.

Cell typeCellular markerProgenitor/Stem cellsLineage cell type(s)Candidate nichesReference(s)

Basal cellsCytokeratin 5, cytokeratin 14YesBasal, secretory, mucous, ciliated cells, PNECSMGs, NEBs, intercartilaginous zone[1315, 40]
Club cellsCCSP, CyP450 2F2YesClub, mucous, ciliated, AEC I, AEC II cells, PNECNEBs, BADJ[2, 5, 18, 86]
Ciliated cellsFoxJ1, Tubulin IVSMGs[61, 87, 88]
Mucous cellsMucin 5AC, Mucin 5BYesBasal, mucous, ciliated cellsSMGs[12, 37, 89]
AEC I cellsAquaporin 5NoAEC I[4, 22, 89]
A EC II cellsSPA, SPB, SPC, LysoTracker DND-26, Aquaporin 1YesAEC I, AEC II, club cells, PNECAlveoli space[4, 22, 23, 33, 50, 90]
PNECCGRPNoClub cellsNEB[2, 63, 91]