Dynamic Network-Based Relevance Score Reveals Essential Proteins and Functional Modules in Directed Differentiation

Figure 4

The interaction activity variations of the integrin functional module in the directed differentiation process at two differentiation stage transitions. (a) Interaction activity variations from the LSB stage to the LSB/S/F8 stage. (b) Interaction activity variations from the LSB/S/F8 stage to the LSB/S/F8/CHIR stage. Node and edge colors and edge line styles have the same interpretation as in Figure 2. The rounded squares are the core subnetworks in the integrin functional module.

(a) LSB → LSB/S/F8

(b) LSB/S/F8 → LSB/S/F8/CHIR