Research Article

Dynamic Network-Based Relevance Score Reveals Essential Proteins and Functional Modules in Directed Differentiation

Table 2

(a) The ten functions highest in relevance score from the LSB to LSB/S/F8 condition. (b) The ten functions highest in relevance score from the LSB/S/F8 to LSB/S/F8/CHIR condition.
(a)

RankLSB → LSB/S/F8
Relevance scoreFunctionP value of ontology analysis

17.627697307Huntington disease
25.389941296Integrin signaling pathway
34.865942264Gonadotropin releasing hormone receptor pathway
44.776453757Angiogenesis
53.318549657PDGF signaling pathway
63.13212684Cytoskeletal regulation by Rho GTPase
73.120593534FGF signaling pathway
83.016342937EGF receptor signaling pathway
92.417680991TGF-beta signaling pathway
102.36486466Parkinson disease

(b)

RankLSB/S/F8 → LSB/S/F8/CHIR
Relevance scoreFunctionP value of ontology analysis

17.085580216Gonadotropin releasing hormone receptor pathway
26.595569241Integrin signaling pathway
34.956190934FGF signaling pathway
44.634381934Angiogenesis
54.535296087EGF receptor signaling pathway
63.702903524Huntington disease
73.299706184PDGF signaling pathway
82.664383051Parkinson disease
92.640768983TGF-beta signaling pathway
102.61175047 RAS pathway