Research Article

Adipose-Derived Mesenchymal Stem Cell Exosomes Suppress Hepatocellular Carcinoma Growth in a Rat Model: Apparent Diffusion Coefficient, Natural Killer T-Cell Responses, and Histopathological Features

Table 3

Comparisons of percentages of circulating NKT-cells at different time points, HCC differentiation, and intratumoral CD8α+ NKT-cells between the control group and exosome-treated group.

Control
mean ± SD
()
Exosome-treated
mean ± SD
()

Circulating NKT-cells (%)
 Before HCC induction0.45 ± 0.350.55 ± 0.36.574*
 Pretreatment1.28 ± 0.371.25 ± 0.33.878*
 Posttreatment day 51.43 ± 0.472.63 ± 0.59.001*
 Posttreatment day 10 0.69 ± 0.292.44 ± 0.57<.001*
HCC tumor differentiation
 E-S grade (I-II : III-IV) 1 : 78 : 0<.001
Intratumoral NKT-cells
 Number of CD8α+ cells/HPF5.1 ± 2.718.7 ± 3.5<.001*

NKT-cells: natural killer T-cells, E-S: Edmondson-Steiner, HPF: high power field.
Mann-Whitney test.
Fisher’s exact test.