Allogeneic juvenile articular nondisc chondrocytes (JCs) and allogeneic bone marrow MSCs
Injection of MSCs or chondrocytes in fibrin carrier
(i) Higher GAG and DNA content in JC group (ii) JC group higher cartilage/collagen II production (iii) JC cells viable at 12 months (iv) MSCs not viable at 3 months and no evidence of PG production
Bilaminar coculture pellets (BCPs) of MSCs and NPCs in a fibrin sealant
(i) Increased disc height in BCP group – combined MSC + NPC (ii) PG produced by BCP (iii) Less viability of MSCs in disc compared to NPCs, otherwise no differences between MSCs and NPCs