Sonic Hedgehog Produced by Bone Marrow-Derived Mesenchymal Stromal Cells Supports Cell Survival in Myelodysplastic Syndrome

Table 1

The characteristics of myelodysplastic syndrome patients.

Number	Diagnosis	Age/sex	Marrow blasts (%)	Karyotype	IPSS
(1)	RA	39/F	0	46,XX[16	0
(2)	RA	70/M	0	46,XY[20	0
(3)	RA	54/F	2	46,XX[5	0
(4)	RARS	65/F	2	46,XX[22	0
(5)	RA	61/M	0	46,XY[4	0
(6)	RARS	65/M	3	46,XY[7	0
(7)	RA	18/F	0	46,XX[7	0
(8)	RA	69/F	0	46,XX[16	0
(9)	RCMD	30/M	0	46,XY,add(7)(q33),del(21)(q22)[10/46,XY[10	1.5
(10)	RCMD	21/M	1	46,XY[20	0.5
(11)	RCMD	61/F	0	46,XX[6	0.5
(12)	RCMD	56/M	2	45,X,−Y[12/46,XY[3	0.5
(13)	RAEB1	56/M	7	46,XY[8	1.0
(14)	RCMD	62/M	3	46,XY,del(1)(p12p32)[6/47,idem, +del(1)(p12p32)[4/46,XY(10)	1.0
(15)	RAEB1	62/F	8	47,XX,+8[15/46,XX[3	1.5
(16)	RCMD	69/M	2	46,XY[6	0.5
(17)	RCMD	38/M	2	46,XY[11	0.5
(18)	RAEB1	73/M	7	47,XY,+8[25	1.0
(19)	RAEB2	61/M	17	47,XY,+8[15/46,XY[10	2.5
(20)	RAEB2	43/F	11	46,XX,inv(3)(q21q26)[16/46,XX[4	2.5
(21)	RAEB2	73/M	18	46,XY,+8[12/46,XY[3	2.5
(22)	RAEB2	71/M	12	45,XY,−7[8/46,XY,	3.0
(23)	RAEB2	64/M	16	46,XY,del(5)(q31,q34)[9/46,XY[5	2.5

F and M indicate female and male; IPSS, International Prognostic Scoring System; RA, refractory anemia; RARS, refractory anemia with ringed sideroblasts; RCMD, refractory cytopenia with multilineage dysplasia; RAEB, RA with excess blasts.