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Stem Cells International
Volume 2015 (2015), Article ID 974864, 12 pages
http://dx.doi.org/10.1155/2015/974864
Review Article

Low Reactive Level Laser Therapy for Mesenchymal Stromal Cells Therapies

Department of Medical Engineering, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan

Received 19 September 2014; Accepted 14 March 2015

Academic Editor: Mark F. Pittenger

Copyright © 2015 Toshihiro Kushibiki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. I. Sikavitsas, J. S. Temenoff, and A. G. Mikos, “Biomaterials and bone mechanotransduction,” Biomaterials, vol. 22, no. 19, pp. 2581–2593, 2001. View at Publisher · View at Google Scholar · View at Scopus
  2. T. Kushibiki and K. Awazu, “Controlling osteogenesis and adipogenesis of mesenchymal stromal cells by regulating a circadian clock protein with laser irradiation,” International Journal of Medical Sciences, vol. 5, no. 6, pp. 319–326, 2008. View at Google Scholar · View at Scopus
  3. T. Kushibiki and K. Awazu, “Blue laser irradiation enhances extracellular calcification of primary mesenchymal stem cells,” Photomedicine and Laser Surgery, vol. 27, no. 3, pp. 493–498, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. T. Kushibiki, T. Tajiri, Y. Ninomiya, and K. Awazu, “Chondrogenic mRNA expression in prechondrogenic cells after blue laser irradiation,” Journal of Photochemistry and Photobiology B: Biology, vol. 98, no. 3, pp. 211–215, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. T. H. Maiman, “Stimulated optical radiation in Ruby,” Nature, vol. 187, no. 4736, pp. 493–494, 1960. View at Publisher · View at Google Scholar · View at Scopus
  6. K. A. Khatri, D. L. Mahoney, and M. J. McCartney, “Laser scar revision: a review,” Journal of Cosmetic and Laser Therapy, vol. 13, no. 2, pp. 54–62, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. S. H. Chung and E. Mazur, “Surgical applications of femtosecond lasers,” Journal of Biophotonics, vol. 2, no. 10, pp. 557–572, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. Z. Zhao and F. Wu, “Minimally-invasive thermal ablation of early-stage breast cancer: a systemic review,” European Journal of Surgical Oncology, vol. 36, no. 12, pp. 1149–1155, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. B. Siribumrungwong, P. Noorit, C. Wilasrusmee, J. Attia, and A. Thakkinstian, “A systematic review and meta-analysis of randomised controlled trials comparing endovenous ablation and surgical intervention in patients with varicose vein,” European Journal of Vascular and Endovascular Surgery, vol. 44, no. 2, pp. 214–223, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. M. E. Vuylsteke and S. R. Mordon, “Endovenous laser ablation: a review of mechanisms of action,” Annals of Vascular Surgery, vol. 26, no. 3, pp. 424–433, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Vogel and V. Venugopalan, “Mechanisms of pulsed laser ablation of biological tissues,” Chemical Reviews, vol. 103, no. 2, pp. 577–644, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Casas, G. Di Venosa, T. Hasan, and A. Batlle, “Mechanisms of resistance to photodynamic therapy,” Current Medicinal Chemistry, vol. 18, no. 16, pp. 2486–2515, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Anand, B. J. Ortel, S. P. Pereira, T. Hasan, and E. V. Maytin, “Biomodulatory approaches to photodynamic therapy for solid tumors,” Cancer Letters, vol. 326, no. 1, pp. 8–16, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. E. Mester, B. Szende, and P. Gärtner, “The effect of laser beams on the growth of hair in mice,” Radiobiologia, Radiotherapia, vol. 9, no. 5, pp. 621–626, 1968. View at Google Scholar · View at Scopus
  15. R. Roelandts, “The history of phototherapy: something new under the sun?” Journal of the American Academy of Dermatology, vol. 46, no. 6, pp. 926–930, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. E. Mester, T. Spiry, B. Szende, and J. G. Tota, “Effect of laser rays on wound healing,” The American Journal of Surgery, vol. 122, no. 4, pp. 532–535, 1971. View at Publisher · View at Google Scholar · View at Scopus
  17. J. P. da Silva, M. A. da Silva, A. P. F. Almeida, I. Lombardi Junior, and A. P. Matos, “Laser therapy in the tissue repair process: a literature review,” Photomedicine and Laser Surgery, vol. 28, no. 1, pp. 17–21, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. W. Posten, D. A. Wrone, J. S. Dover, K. A. Arndt, S. Silapunt, and M. Alam, “Low-level laser therapy for wound healing: mechanism and efficacy,” Dermatologic Surgery, vol. 31, no. 3, pp. 334–340, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. P. V. Peplow and G. D. Baxter, “Gene expression and release of growth factors during delayed wound healing: a review of studies in diabetic animals and possible combined laser phototherapy and growth factor treatment to enhance healing,” Photomedicine and Laser Surgery, vol. 30, no. 11, pp. 617–636, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. P. V. Peplow, T.-Y. Chung, and G. D. Baxter, “Photodynamic modulation of wound healing: a review of human and animal studies,” Photomedicine and Laser Surgery, vol. 30, no. 3, pp. 118–148, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. H. S. Yu, K. L. Chang, C. L. Yu, J. W. Chen, and G. S. Chen, “Low-energy helium-neon laser irradiation stimulates interleukin-1alpha and interleukin-8 release from cultured human keratinocytes,” Journal of Investigative Dermatology, vol. 107, no. 4, pp. 593–596, 1996. View at Publisher · View at Google Scholar · View at Scopus
  22. N. Kipshidze, V. Nikolaychik, M. H. Keelan et al., “Low-power helium: neon laser irradiation enhances production of vascular endothelial growth factor and promotes growth of endothelial cells in vitro,” Lasers in Surgery and Medicine, vol. 28, no. 4, pp. 355–364, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Khanna, L. R. Shankar, M. H. Keelan et al., “Augmentation of the expression of proangiogenic genes in cardiomyocytes with low dose laser irradiation In vitro,” Cardiovascular Radiation Medicine, vol. 1, no. 3, pp. 265–269, 1999. View at Publisher · View at Google Scholar · View at Scopus
  24. F. Correa, R. A. Lopes Martins, J. C. Correa, V. V. Iversen, J. Joenson, and J. M. Bjordal, “Low-level laser therapy (GaAs lambda = 904 nm) reduces inflammatory cell migration in mice with lipopolysaccharide-induced peritonitis,” Photomedicine and laser surgery, vol. 25, no. 4, pp. 245–249, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. E. S. Boschi, C. E. Leite, V. C. Saciura et al., “Anti-inflammatory effects of low-level laser therapy (660 nm) in the early phase in carrageenan-induced pleurisy in rat,” Lasers in Surgery and Medicine, vol. 40, no. 7, pp. 500–508, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. F. Aimbire, R. Albertini, M. T. T. Pacheco et al., “Low-level laser therapy induces dose-dependent reduction of TNFα levels in acute inflammation,” Photomedicine and Laser Surgery, vol. 24, no. 1, pp. 33–37, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. F. Aimbire, A. P. Ligeiro De Oliveira, R. Albertini et al., “Low level laser therapy (LLLT) decreases pulmonary microvascular leakage, neutrophil influx and IL-1β levels in airway and lung from rat subjected to LPS-induced inflammation,” Inflammation, vol. 31, no. 3, pp. 189–197, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. F. Aimbire, F. V. Santos, R. Albertini, H. C. Castro-Faria-Neto, J. Mittmann, and C. Pacheco-Soares, “Low-level laser therapy decreases levels of lung neutrophils anti-apoptotic factors by a NF-κB dependent mechanism,” International Immunopharmacology, vol. 8, no. 4, pp. 603–605, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. R. Albertini, F. Aimbire, A. B. Villaverde, J. A. Silva Jr., and M. S. Costa, “COX-2 mRNA expression decreases in the subplantar muscle of rat paw subjected to carrageenan-induced inflammation after low level laser therapy,” Inflammation Research, vol. 56, no. 6, pp. 228–229, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. R. Albertini, F. S. C. Aimbire, F. I. Correa et al., “Effects of different protocol doses of low power gallium-aluminum-arsenate (Ga-Al-As) laser radiation (650 nm) on carrageenan induced rat paw ooedema,” Journal of Photochemistry and Photobiology B: Biology, vol. 74, no. 2-3, pp. 101–107, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. R. Albertini, A. B. Villaverde, F. Aimbire et al., “Cytokine mRNA expression is decreased in the subplantar muscle of rat paw subjected to carrageenan-induced inflammation after low-level laser therapy,” Photomedicine and Laser Surgery, vol. 26, no. 1, pp. 19–24, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. R. Albertini, A. B. Villaverde, F. Aimbire et al., “Anti-inflammatory effects of low-level laser therapy (LLLT) with two different red wavelengths (660 nm and 684 nm) in carrageenan-induced rat paw edema,” Journal of Photochemistry and Photobiology B: Biology, vol. 89, no. 1, pp. 50–55, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. A. C. A. Alves, R. D. P. Vieira, E. C. P. Leal-Junior et al., “Effect of low-level laser therapy on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation,” Arthritis Research & Therapy, vol. 15, no. 5, article R116, 2013. View at Publisher · View at Google Scholar · View at Scopus
  34. F. Bortone, H. A. Santos, R. Albertini, J. B. Pesquero, M. S. Costa, and J. A. Silva Jr., “Low level laser therapy modulates kinin receptors mRNA expression in the subplantar muscle of rat paw subjected to carrageenan-induced inflammation,” International Immunopharmacology, vol. 8, no. 2, pp. 206–210, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. H. L. Casalechi, E. C. P. Leal-Junior, M. Xavier et al., “Low-level laser therapy in experimental model of collagenase-induced tendinitis in rats: Effects in acute and chronic inflammatory phases,” Lasers in Medical Science, vol. 28, no. 3, pp. 989–995, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. P. de Almeida, R. Á. B. Lopes-Martins, S. S. Tomazoni et al., “Low-level laser therapy and sodium diclofenac in acute inflammatory response induced by skeletal muscle trauma: effects in muscle morphology and mRNA gene expression of inflammatory markers,” Photochemistry and Photobiology, vol. 89, no. 2, pp. 501–507, 2013. View at Publisher · View at Google Scholar · View at Scopus
  37. F. M. de Lima, R. Albertini, Y. Dantas et al., “Low-level laser therapy restores the oxidative stress balance in acute lung injury induced by gut ischemia and reperfusion,” Photochemistry and Photobiology, vol. 89, no. 1, pp. 179–188, 2013. View at Publisher · View at Google Scholar · View at Scopus
  38. F. M. De Lima, A. B. Villaverde, R. Albertini et al., “Dual Effect of low-level laser therapy (LLLT) on the acute lung inflammation induced by intestinal ischemia and reperfusion: action on anti- and pro-inflammatory cytokines,” Lasers in Surgery and Medicine, vol. 43, no. 5, pp. 410–420, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. F. M. de Lima, A. B. Villaverde, R. Albertini, A. P. L. de Oliveira, H. C. C. F. Neto, and F. Aimbire, “Low-level laser therapy associated to N-acetylcysteine lowers macrophage inflammatory protein-2 (MIP-2) mRNA expression and generation of intracellular reactive oxygen species in alveolar macrophages,” Photomedicine and Laser Surgery, vol. 28, no. 6, pp. 763–771, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. E. M. S. Laraia, I. S. Silva, D. M. Pereira et al., “Effect of low-level laser therapy (660 nm) on acute inflammation induced by tenotomy of achilles tendon in rats,” Photochemistry and Photobiology, vol. 88, no. 6, pp. 1546–1550, 2012. View at Publisher · View at Google Scholar · View at Scopus
  41. R. A. B. Lopes-Martins, R. Albertini, P. S. L. Lopes Martins, J. M. Bjordal, and H. C. C. Faria Neto, “Spontaneous effects of low-level laser therapy (650 nm) in acute inflammatory mouse pleurisy induced by carrageenan,” Photomedicine and Laser Surgery, vol. 23, no. 4, pp. 377–381, 2005. View at Publisher · View at Google Scholar · View at Scopus
  42. F. Mafra de Lima, M. S. Costa, R. Albertini, J. A. Silva Jr., and F. Aimbire, “Low level laser therapy (LLLT): attenuation of cholinergic hyperreactivity, β2-adrenergic hyporesponsiveness and TNF-α mRNA expression in rat bronchi segments in E. coli lipopolysaccharide-induced airway inflammation by a NF-κB dependent mechanism,” Lasers in Surgery and Medicine, vol. 41, no. 1, pp. 68–74, 2009. View at Publisher · View at Google Scholar · View at Scopus
  43. F. Mafra de Lima, K. T. Naves, A. H. Machado, R. Albertini, A. B. Villaverde, and F. Aimbire, “Lung inflammation and endothelial cell damage are decreased after treatment with phototherapy (PhT) in a model of acute lung injury induced by Escherichia coli lipopolysaccharide in the rat,” Cell Biology International, vol. 33, no. 12, pp. 1212–1221, 2009. View at Publisher · View at Google Scholar · View at Scopus
  44. F. Mafra de Lima, A. B. Villaverde, M. A. Salgado et al., “Low intensity laser therapy (LILT) in vivo acts on the neutrophils recruitment and chemokines/cytokines levels in a model of acute pulmonary inflammation induced by aerosol of lipopolysaccharide from Escherichia coli in rat,” Journal of Photochemistry and Photobiology B: Biology, vol. 101, no. 3, pp. 271–278, 2010. View at Publisher · View at Google Scholar · View at Scopus
  45. D. Pires, M. Xavier, T. Araújo, J. A. Silva Jr., F. Aimbire, and R. Albertini, “Low-level laser therapy (LLLT; 780 nm) acts differently on mRNA expression of anti- and pro-inflammatory mediators in an experimental model of collagenase-induced tendinitis in rat,” Lasers in Medical Science, vol. 26, no. 1, pp. 85–94, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. M. Xavier, D. R. David, R. A. De Souza et al., “Anti-inflammatory effects of low-level light emitting diode therapy on Achilles tendinitis in rats,” Lasers in Surgery and Medicine, vol. 42, no. 6, pp. 553–558, 2010. View at Publisher · View at Google Scholar · View at Scopus
  47. Y. Ozawa, N. Shimizu, G. Kariya, and Y. Abiko, “Low-energy laser irradiation stimulates bone nodule formation at early stages of cell culture in rat calvarial cells,” Bone, vol. 22, no. 4, pp. 347–354, 1998. View at Publisher · View at Google Scholar · View at Scopus
  48. A. N. Silva Júnior, A. L. B. Pinheiro, M. G. Oliveira, R. Weismann, L. M. Pedreira Ramalho, and R. Amadei Nicolau, “Computerized morphometric assessment of the effect of low-level laser therapy on bone repair: an experimental animal study,” Journal of Clinical Laser Medicine and Surgery, vol. 20, no. 2, pp. 83–87, 2002. View at Publisher · View at Google Scholar · View at Scopus
  49. N. Shimizu, K. Mayahara, T. Kiyosaki, A. Yamaguchi, Y. Ozawa, and Y. Abiko, “Low-intensity laser irradiation stimulates bone nodule formation via insulin-like growth factor-I expression in rat calvarial cells,” Lasers in Surgery and Medicine, vol. 39, no. 6, pp. 551–559, 2007. View at Publisher · View at Google Scholar · View at Scopus
  50. V. Aleksic, A. Aoki, K. Iwasaki et al., “Low-level Er: YAG laser irradiation enhances osteoblast proliferation through activation of MAPK/ERK,” Lasers in Medical Science, vol. 25, no. 4, pp. 559–569, 2010. View at Publisher · View at Google Scholar · View at Scopus
  51. S. Hirata, C. Kitamura, H. Fukushima et al., “Low-level laser irradiation enhances BMP-induced osteoblast differentiation by stimulating the BMP/Smad signaling pathway,” Journal of Cellular Biochemistry, vol. 111, no. 6, pp. 1445–1452, 2010. View at Publisher · View at Google Scholar · View at Scopus
  52. D. Gigo-Benato, T. L. Russo, E. H. Tanaka, L. Assis, T. F. Salvini, and N. A. Parizotto, “Effects of 660 and 780 nm low-level laser therapy on neuromuscular recovery after crush injury in rat sciatic nerve,” Lasers in Surgery and Medicine, vol. 42, no. 9, pp. 673–682, 2010. View at Publisher · View at Google Scholar · View at Scopus
  53. C.-C. Shen, Y.-C. Yang, T.-B. Huang, S.-C. Chan, and B.-S. Liu, “Neural regeneration in a novel nerve conduit across a large gap of the transected sciatic nerve in rats with low-level laser phototherapy,” Journal of Biomedical Materials Research Part: A, vol. 101, no. 10, pp. 2763–2777, 2013. View at Publisher · View at Google Scholar · View at Scopus
  54. D. Gigo-Benato, S. Geuna, and S. Rochkind, “Phototherapy for enhancing peripheral nerve repair: a review of the literature,” Muscle and Nerve, vol. 31, no. 6, pp. 694–701, 2005. View at Publisher · View at Google Scholar · View at Scopus
  55. J. J. Anders, S. Geuna, and S. Rochkind, “Phototherapy promotes regeneration and functional recovery of injured peripheral nerve,” Neurological Research, vol. 26, no. 2, pp. 233–239, 2004. View at Publisher · View at Google Scholar · View at Scopus
  56. M. Bayat, E. Ansari, N. Gholami, and A. Bayat, “Effect of low-level helium-neon laser therapy on histological and ultrastructural features of immobilized rabbit articular cartilage,” Journal of Photochemistry and Photobiology B: Biology, vol. 87, no. 2, pp. 81–87, 2007. View at Publisher · View at Google Scholar · View at Scopus
  57. D. Avni, S. Levkovitz, L. Maltz, and U. Oron, “Protection of skeletal muscles from ischemic injury: low-level laser therapy increases antioxidant activity,” Photomedicine and Laser Surgery, vol. 23, no. 3, pp. 273–277, 2005. View at Publisher · View at Google Scholar · View at Scopus
  58. R. Á. B. Lopes-Martins, R. L. Marcos, P. S. Leonardo et al., “Effect of low-level laser (Ga-Al-As 655 nm) on skeletal muscle fatigue induced by electrical stimulation in rats,” Journal of Applied Physiology, vol. 101, no. 1, pp. 283–288, 2006. View at Publisher · View at Google Scholar · View at Scopus
  59. E. C. P. Leal, R. Á. B. Lopes-Martins, F. Dalan et al., “Effect of 655-nm low-level laser therapy on exercise-induced skeletal muscle fatigue in humans,” Photomedicine and Laser Surgery, vol. 26, no. 5, pp. 419–424, 2008. View at Publisher · View at Google Scholar · View at Scopus
  60. K. M. AlGhamdi, A. Kumar, and N. A. Moussa, “Low-level laser therapy: a useful technique for enhancing the proliferation of various cultured cells,” Lasers in Medical Science, vol. 27, no. 1, pp. 237–249, 2012. View at Publisher · View at Google Scholar · View at Scopus
  61. X. Gao and D. Xing, “Molecular mechanisms of cell proliferation induced by low power laser irradiation,” Journal of Biomedical Science, vol. 16, no. 1, article 4, 2009. View at Publisher · View at Google Scholar · View at Scopus
  62. J. Tafur, E. P. A. van Wijk, R. van Wijk, and P. J. Mills, “Biophoton detection and low-intensity light therapy: a potential clinical partnership,” Photomedicine and laser surgery, vol. 28, no. 1, pp. 23–30, 2010. View at Publisher · View at Google Scholar · View at Scopus
  63. L. Gavish, L. S. Perez, P. Reissman, and S. D. Gertz, “Irradiation with 780 nm diode laser attenuates inflammatory cytokines but upregulates nitric oxide in lipopolysaccharide-stimulated macrophages: implications for the prevention of aneurysm progression,” Lasers in Surgery and Medicine, vol. 40, no. 5, pp. 371–378, 2008. View at Publisher · View at Google Scholar · View at Scopus
  64. A. Lindgård, L. M. Hultén, L. Svensson, and B. Soussi, “Irradiation at 634 nm releases nitric oxide from human monocytes,” Lasers in Medical Science, vol. 22, no. 1, pp. 30–36, 2007. View at Publisher · View at Google Scholar · View at Scopus
  65. Y. Moriyama, E. H. Moriyama, K. Blackmore, M. K. Akens, and L. Lilge, “In vivo study of the inflammatory modulating effects of low-level laser therapy on iNOS expression using bioluminescence imaging,” Photochemistry and Photobiology, vol. 81, no. 6, pp. 1351–1355, 2005. View at Publisher · View at Google Scholar · View at Scopus
  66. Y. Moriyama, J. Nguyen, M. Akens, E. H. Moriyama, and L. Lilge, “In vivo effects of low level laser therapy on inducible nitric oxide synthase,” Lasers in Surgery and Medicine, vol. 41, no. 3, pp. 227–231, 2009. View at Publisher · View at Google Scholar · View at Scopus
  67. H. Tuby, L. Maltz, and U. Oron, “Modulations of VEGF and iNOS in the rat heart by low level laser therapy are associated with cardioprotection and enhanced angiogenesis,” Lasers in Surgery and Medicine, vol. 38, no. 7, pp. 682–688, 2006. View at Publisher · View at Google Scholar · View at Scopus
  68. T. Y. Fukuda, M. M. Tanji, S. R. Silva, M. N. Sato, and H. Plapler, “Infrared low-level diode laser on inflammatory process modulation in mice: pro- and anti-inflammatory cytokines,” Lasers in Medical Science, vol. 28, no. 5, pp. 1305–1313, 2013. View at Publisher · View at Google Scholar · View at Scopus
  69. R. G. Oliveira, A. P. Ferreira, A. J. Côrtes, B. J. V. Aarestrup, L. C. Andrade, and F. M. Aarestrup, “Low-level laser reduces the production of TNF-α, IFN-γ, and IL-10 induced by OVA,” Lasers in Medical Science, vol. 28, no. 6, pp. 1519–1525, 2013. View at Publisher · View at Google Scholar · View at Scopus
  70. M. Yamaura, M. Yao, I. Yaroslavsky, R. Cohen, M. Smotrich, and I. E. Kochevar, “Low level light effects on inflammatory cytokine production by rheumatoid arthritis synoviocytes,” Lasers in Surgery and Medicine, vol. 41, no. 4, pp. 282–290, 2009. View at Publisher · View at Google Scholar · View at Scopus
  71. S. M. Safavi, B. Kazemi, M. Esmaeili, A. Fallah, A. Modarresi, and M. Mir, “Effects of low-level He-Ne laser irradiation on the gene expression of IL-1β, TNF-α, IFN-γ, TGF-β, bFGF, and PDGF in rat's gingiva,” Lasers in Medical Science, vol. 23, no. 3, pp. 331–335, 2008. View at Publisher · View at Google Scholar · View at Scopus
  72. H. Shiba, H. Tsuda, M. Kajiya et al., “Neodymium-doped yttrium-aluminium-garnet laser irradiation abolishes the increase in interleukin-6 levels caused by peptidoglycan through the p38 mitogen-activated protein kinase pathway in human pulp cells,” Journal of Endodontics, vol. 35, no. 3, pp. 373–376, 2009. View at Publisher · View at Google Scholar · View at Scopus
  73. N. N. Houreld, P. R. Sekhejane, and H. Abrahamse, “Irradiation at 830 nm stimulates nitric oxide production and inhibits pro-inflammatory cytokines in diabetic wounded fibroblast cells,” Lasers in Surgery and Medicine, vol. 42, no. 6, pp. 494–502, 2010. View at Publisher · View at Google Scholar · View at Scopus
  74. M. Šimunović-Šoškić, S. Pezelj-Ribarić, G. Brumini, I. Glažar, R. Gržić, and I. Miletić, “Salivary levels of TNF-alpha and IL-6 in patients with denture stomatitis before and after laser phototherapy,” Photomedicine and Laser Surgery, vol. 28, no. 2, pp. 189–193, 2010. View at Publisher · View at Google Scholar · View at Scopus
  75. T. Fushimi, S. Inui, T. Nakajima, M. Ogasawara, K. Hosokawa, and S. Itami, “Green light emitting diodes accelerate wound healing: characterization of the effect and its molecular basis in vitro and in vivo,” Wound Repair and Regeneration, vol. 20, no. 2, pp. 226–235, 2012. View at Publisher · View at Google Scholar · View at Scopus
  76. I. Saygun, S. Karacay, M. Serdar, A. U. Ural, M. Sencimen, and B. Kurtis, “Effects of laser irradiation on the release of basic fibroblast growth factor (bFGF), insulin like growth factor-1 (IGF-1), and receptor of IGF-1 (IGFBP3) from gingival fibroblasts,” Lasers in Medical Science, vol. 23, no. 2, pp. 211–215, 2008. View at Publisher · View at Google Scholar · View at Scopus
  77. F. Schwartz, C. Brodie, E. Appel, G. Kazimirsky, and A. Shainberg, “Effect of helium/neon laser irradiation on nerve growth factor synthesis and secretion in skeletal muscle cultures,” Journal of Photochemistry and Photobiology B: Biology, vol. 66, no. 3, pp. 195–200, 2002. View at Publisher · View at Google Scholar · View at Scopus
  78. W. Yu, J. O. Naim, and R. J. Lanzafame, “The effect of laser irradiation on the release of bFGF from 3T3 fibroblasts,” Photochemistry and Photobiology, vol. 59, no. 2, pp. 167–170, 1994. View at Publisher · View at Google Scholar · View at Scopus
  79. W. P. Hu, J. J. Wang, C. L. Yu, C. C. E. Lan, G. S. Chen, and H. S. Yu, “Helium-neon laser irradiation stimulates cell proliferation through photostimulatory effects in mitochondria,” Journal of Investigative Dermatology, vol. 127, no. 8, pp. 2048–2057, 2007. View at Publisher · View at Google Scholar · View at Scopus
  80. C.-C. E. Lan, C.-S. Wu, M.-H. Chiou, T.-Y. Chiang, and H.-S. Yu, “Low-energy helium-neon laser induces melanocyte proliferation via interaction with type IV collagen: visible light as a therapeutic option for vitiligo,” British Journal of Dermatology, vol. 161, no. 2, pp. 273–280, 2009. View at Publisher · View at Google Scholar · View at Scopus
  81. S. Wu, D. Xing, X. Gao, and W. R. Chen, “High fluence low-power laser irradiation induces mitochondrial permeability transition mediated by reactive oxygen species,” Journal of Cellular Physiology, vol. 218, no. 3, pp. 603–611, 2009. View at Publisher · View at Google Scholar · View at Scopus
  82. I. L. Zungu, D. Hawkins Evans, and H. Abrahamse, “Mitochondrial responses of normal and injured human skin fibroblasts following low level laser irradiation—an in vitro study,” Photochemistry and Photobiology, vol. 85, no. 4, pp. 987–996, 2009. View at Publisher · View at Google Scholar · View at Scopus
  83. T. Karu, “Photobiology of low-power laser effects,” Health Physics, vol. 56, no. 5, pp. 691–704, 1989. View at Publisher · View at Google Scholar · View at Scopus
  84. T. I. Karu, “Mitochondrial signaling in mammalian cells activated by red and near-IR radiation,” Photochemistry and Photobiology, vol. 84, no. 5, pp. 1091–1099, 2008. View at Publisher · View at Google Scholar · View at Scopus
  85. O. Tiphlova and T. Karu, “Role of primary photoacceptors in low-power laser effects: action of He-Ne laser radiation on bacteriophage T4-Escherichia coli interaction,” Lasers in Surgery and Medicine, vol. 9, no. 1, pp. 67–69, 1989. View at Publisher · View at Google Scholar · View at Scopus
  86. L. Zhang, D. Xing, D. Zhu, and Q. Chen, “Low-power laser irradiation inhibiting Abeta25-35-induced PC12 cell apoptosis via PKC activation,” Cellular Physiology and Biochemistry, vol. 22, no. 1–4, pp. 215–222, 2008. View at Publisher · View at Google Scholar · View at Scopus
  87. T. Kushibiki, T. Hirasawa, S. Okawa, and M. Ishihara, “Blue laser irradiation generates intracellular reactive oxygen species in various types of cells,” Photomedicine and Laser Surgery, vol. 31, no. 3, pp. 95–104, 2013. View at Publisher · View at Google Scholar · View at Scopus
  88. A. Lipovsky, Y. Nitzan, and R. Lubart, “A possible mechanism for visible light-induced wound healing,” Lasers in Surgery and Medicine, vol. 40, no. 7, pp. 509–514, 2008. View at Publisher · View at Google Scholar · View at Scopus
  89. N. Ignatieva, O. Zakharkina, I. Andreeva, E. Sobol, V. Kamensky, and V. Lunin, “Effects of laser irradiation on collagen organization in chemically induced degenerative annulus fibrosus of lumbar intervertebral disc,” Lasers in Surgery and Medicine, vol. 40, no. 6, pp. 422–432, 2008. View at Publisher · View at Google Scholar · View at Scopus
  90. L. B. Silveira, R. A. Prates, M. D. Novelli et al., “Investigation of mast cells in human gingiva following low-intensity laser irradiation,” Photomedicine and Laser Surgery, vol. 26, no. 4, pp. 315–321, 2008. View at Publisher · View at Google Scholar · View at Scopus
  91. A. R. Coombe, C.-T. G. Ho, M. A. Darendeliler et al., “The effects of low level laser irradiation on osteoblastic cells,” Orthodontics and Craniofacial Research, vol. 4, no. 1, pp. 3–14, 2001. View at Publisher · View at Google Scholar · View at Scopus
  92. J. C. Sutherland, “Biological effects of polychromatic light,” Photochemistry and Photobiology, vol. 76, no. 2, pp. 164–170, 2002. View at Publisher · View at Google Scholar · View at Scopus
  93. T. I. Karu, L. V. Pyatibrat, S. F. Kolyakov, and N. I. Afanasyeva, “Absorption measurements of a cell monolayer relevant to phototherapy: reduction of cytochrome c oxidase under near IR radiation,” Journal of Photochemistry and Photobiology B: Biology, vol. 81, no. 2, pp. 98–106, 2005. View at Publisher · View at Google Scholar · View at Scopus
  94. M. T. T. Wong-Riley, H. L. Liang, J. T. Eells et al., “Photobiomodulation directly benefits primary neurons functionally inactivated by toxins: Role of cytochrome c oxidase,” The Journal of Biological Chemistry, vol. 280, no. 6, pp. 4761–4771, 2005. View at Publisher · View at Google Scholar · View at Scopus
  95. D. Pastore, M. Greco, V. A. Petragallo, and S. Passarella, “Increase in H+/e- ratio of the cytochrome c oxidase reaction in mitochondria irradiated with Helium-Neon laser,” Biochemistry and Molecular Biology International, vol. 34, no. 4, pp. 817–826, 1994. View at Google Scholar · View at Scopus
  96. D. Barolet, P. Duplay, H. Jacomy, and M. Auclair, “Importance of pulsing illumination parameters in low-level-light therapy,” Journal of Biomedical Optics, vol. 15, no. 4, Article ID 048005, 2010. View at Publisher · View at Google Scholar · View at Scopus
  97. J. Chu, S. Wu, and D. Xing, “Survivin mediates self-protection through ROS/cdc25c/CDK1 signaling pathway during tumor cell apoptosis induced by high fluence low-power laser irradiation,” Cancer Letters, vol. 297, no. 2, pp. 207–219, 2010. View at Publisher · View at Google Scholar · View at Scopus
  98. T. I. Karu, L. V. Pyatibrat, and N. I. Afanasyeva, “Cellular effects of low power laser therapy can be mediated by nitric oxide,” Lasers in Surgery and Medicine, vol. 36, no. 4, pp. 307–314, 2005. View at Publisher · View at Google Scholar · View at Scopus
  99. C.-C. E. Lan, S.-B. Wu, C.-S. Wu et al., “Induction of primitive pigment cell differentiation by visible light (helium-neon laser): a photoacceptor-specific response not replicable by UVB irradiation,” Journal of Molecular Medicine, vol. 90, no. 3, pp. 321–330, 2012. View at Publisher · View at Google Scholar · View at Scopus
  100. J. Lim, R. A. Sanders, A. C. Snyder, J. T. Eells, D. S. Henshel, and J. B. Watkins, “Effects of low-level light therapy on streptozotocin-induced diabetic kidney,” Journal of Photochemistry and Photobiology B: Biology, vol. 99, no. 2, pp. 105–110, 2010. View at Publisher · View at Google Scholar · View at Scopus
  101. L. Santana-Blank, E. Rodríguez-Santana, and K. Santana-Rodríguez, “Theoretic, experimental, clinical bases of the water oscillator hypothesis in near-infrared photobiomodulation,” Photomedicine and Laser Surgery, vol. 28, no. 1, pp. S41–S52, 2010. View at Publisher · View at Google Scholar · View at Scopus
  102. P. C. L. Silveira, E. L. Streck, and R. A. Pinho, “Evaluation of mitochondrial respiratory chain activity in wound healing by low-level laser therapy,” Journal of Photochemistry and Photobiology B: Biology, vol. 86, no. 3, pp. 279–282, 2007. View at Publisher · View at Google Scholar · View at Scopus
  103. Z.-H. Wu, Y. Zhou, J.-Y. Chen, and L.-W. Zhou, “Mitochondrial signaling for histamine releases in laser-irradiated RBL-2H3 mast cells,” Lasers in Surgery and Medicine, vol. 42, no. 6, pp. 503–509, 2010. View at Publisher · View at Google Scholar · View at Scopus
  104. S. Verma, G. M. Watt, Z. Mai, and T. Hasan, “Strategies for enhanced photodynamic therapy effects,” Photochemistry and Photobiology, vol. 83, no. 5, pp. 996–1005, 2007. View at Publisher · View at Google Scholar · View at Scopus
  105. V. Massey, “The chemical and biological versatility of riboflavin,” Biochemical Society Transactions, vol. 28, no. 4, pp. 283–296, 2000. View at Publisher · View at Google Scholar · View at Scopus
  106. M. Eichler, R. Lavi, A. Shainberg, and R. Lubart, “Flavins are source of visible-light-induced free radical formation in cells,” Lasers in Surgery and Medicine, vol. 37, no. 4, pp. 314–319, 2005. View at Publisher · View at Google Scholar · View at Scopus
  107. F. Q. Schafer and G. R. Buettner, “Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple,” Free Radical Biology and Medicine, vol. 30, no. 11, pp. 1191–1212, 2001. View at Publisher · View at Google Scholar · View at Scopus
  108. P. Storz, “Mitochondrial ROS—radical detoxification, mediated by protein kinase D,” Trends in Cell Biology, vol. 17, no. 1, pp. 13–18, 2007. View at Publisher · View at Google Scholar · View at Scopus
  109. H. Liu, R. Colavitti, I. I. Rovira, and T. Finkel, “Redox-dependent transcriptional regulation,” Circulation Research, vol. 97, no. 10, pp. 967–974, 2005. View at Publisher · View at Google Scholar · View at Scopus
  110. K. Irani, Y. Xia, J. L. Zweier et al., “Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts,” Science, vol. 275, no. 5306, pp. 1649–1652, 1997. View at Publisher · View at Google Scholar · View at Scopus
  111. R. Schreck and A. Baeuerle, “A role for oxygen radicals as second messengers,” Trends in Cell Biology, vol. 1, no. 2-3, pp. 39–42, 1991. View at Publisher · View at Google Scholar · View at Scopus
  112. W. Dröge, “Free radicals in the physiological control of cell function,” Physiological Reviews, vol. 82, no. 1, pp. 47–95, 2002. View at Google Scholar · View at Scopus
  113. R. Lavi, A. Shainberg, H. Friedmann et al., “Low energy visible light induces reactive oxygen species generation and stimulates an increase of intracellular calcium concentration in cardiac cells,” The Journal of Biological Chemistry, vol. 278, no. 42, pp. 40917–40922, 2003. View at Publisher · View at Google Scholar · View at Scopus
  114. V. Borutaite, A. Budriunaite, and G. C. Brown, “Reversal of nitric oxide-, peroxynitrite- and S-nitrosothiol-induced inhibition of mitochondrial respiration or complex I activity by light and thiols,” Biochimica et Biophysica Acta: Bioenergetics, vol. 1459, no. 2-3, pp. 405–412, 2000. View at Publisher · View at Google Scholar · View at Scopus
  115. G. A. Guzzardella, M. Fini, P. Torricelli, G. Giavaresi, and R. Giardino, “Laser stimulation on bone defect healing: an in vitro study,” Lasers in Medical Science, vol. 17, no. 3, pp. 216–220, 2002. View at Publisher · View at Google Scholar · View at Scopus
  116. M. C. P. Leung, S. C. L. Lo, F. K. W. Siu, and K.-F. So, “Treatment of experimentally induced transient cerebral ischemia with low energy laser inhibits nitric oxide synthase activity and up-regulates the expression of transforming growth factor-beta 1,” Lasers in Surgery and Medicine, vol. 31, no. 4, pp. 283–288, 2002. View at Publisher · View at Google Scholar · View at Scopus
  117. M. Eichler, R. Lavi, H. Friedmann, A. Shainberg, and R. Lubart, “Red light-induced redox reactions in cells observed with TEMPO,” Photomedicine and Laser Surgery, vol. 25, no. 3, pp. 170–174, 2007. View at Publisher · View at Google Scholar · View at Scopus
  118. C. F. Rizzi, J. L. Mauriz, D. S. F. Corrêa et al., “Effects of low-level laser therapy (LLLT) on the nuclear factor (NF)-κB signaling pathway in traumatized muscle,” Lasers in Surgery and Medicine, vol. 38, no. 7, pp. 704–713, 2006. View at Publisher · View at Google Scholar · View at Scopus
  119. C. T. Taylor, “Mitochondria and cellular oxygen sensing in the HIF pathway,” Biochemical Journal, vol. 409, no. 1, pp. 19–26, 2008. View at Publisher · View at Google Scholar · View at Scopus
  120. E. Shaulian and M. Karin, “AP-1 as a regulator of cell life and death,” Nature Cell Biology, vol. 4, no. 5, pp. E131–E136, 2002. View at Publisher · View at Google Scholar · View at Scopus
  121. S. Bergelson, R. Pinkus, and V. Daniel, “Intracellular glutathione levels regulate Fos/Jun induction and activation of glutathione S-transferase gene expression,” Cancer Research, vol. 54, no. 1, pp. 36–40, 1994. View at Google Scholar · View at Scopus
  122. D. M. Flaherty, M. M. Monick, A. B. Carter, M. W. Peterson, and G. W. Hunninghake, “Oxidant-mediated increases in redox factor-1 nuclear protein and activator protein-1 DNA binding in asbestos-treated macrophages,” The Journal of Immunology, vol. 168, no. 11, pp. 5675–5681, 2002. View at Publisher · View at Google Scholar · View at Scopus
  123. C. Lee, J.-P. Etchegaray, F. R. A. Cagampang, A. S. I. Loudon, and S. M. Reppert, “Posttranslational mechanisms regulate the mammalian circadian clock,” Cell, vol. 107, no. 7, pp. 855–867, 2001. View at Publisher · View at Google Scholar · View at Scopus
  124. L. Fu, M. S. Patel, A. Bradley, E. F. Wagner, and G. Karsenty, “The molecular clock mediates leptin-regulated bone formation,” Cell, vol. 122, no. 5, pp. 803–815, 2005. View at Publisher · View at Google Scholar · View at Scopus
  125. S. Kawasaki, S. Ebara, K. Nakayama, and K. Takaoka, “The E-box motif, recognized by tissue-specific nuclear factor(s), is important for BMP-4 gene expression in osteogenic cells,” Biochemical and Biophysical Research Communications, vol. 263, no. 2, pp. 560–565, 1999. View at Publisher · View at Google Scholar · View at Scopus
  126. I.-S. Park, P.-S. Chung, and J. C. Ahn, “Enhanced angiogenic effect of adipose-derived stromal cell spheroid with low-level light therapy in hind limb ischemia mice,” Biomaterials, vol. 35, no. 34, pp. 9280–9289, 2014. View at Publisher · View at Google Scholar
  127. D. Farfara, H. Tuby, D. Trudler et al., “Low-level laser therapy ameliorates disease progression in a mouse model of Alzheimer's disease,” Journal of Molecular Neuroscience, vol. 55, no. 2, pp. :430–436, 2015. View at Publisher · View at Google Scholar
  128. C.-C. Yang, J. Wang, S.-C. Chen, and Y.-L. Hsieh, “Synergistic effects of low-level laser and mesenchymal stem cells on functional recovery in rats with crushed sciatic nerves,” Journal of Tissue Engineering and Regenerative Medicine, 2013. View at Publisher · View at Google Scholar · View at Scopus
  129. J.-Y. Wu, C.-H. Chen, C.-Z. Wang, M.-L. Ho, M.-L. Yeh, and Y.-H. Wang, “Low-power laser irradiation suppresses inflammatory response of human adipose-derived stem cells by modulating intracellular cyclic AMP level and NF-kappaB activity,” PLoS ONE, vol. 8, no. 1, Article ID e54067, 2013. View at Publisher · View at Google Scholar · View at Scopus
  130. M. J. H. Nagata, C. S. Santinoni, N. M. Pola et al., “Bone marrow aspirate combined with low-level laser therapy: a new therapeutic approach to enhance bone healing,” Journal of Photochemistry and Photobiology B: Biology, vol. 121, pp. 6–14, 2013. View at Publisher · View at Google Scholar · View at Scopus
  131. R. Manuguerra-Gagné, P. R. Boulos, A. Ammar et al., “Transplantation of mesenchymal stem cells promotes tissue regeneration in a glaucoma model through laser-induced paracrine factor secretion and progenitor cell recruitment,” Stem Cells, vol. 31, no. 6, pp. 1136–1148, 2013. View at Publisher · View at Google Scholar · View at Scopus
  132. A. Lipovsky, U. Oron, A. Gedanken, and R. Lubart, “Low-level visible light (LLVL) irradiation promotes proliferation of mesenchymal stem cells,” Lasers in Medical Science, vol. 28, no. 4, pp. 1113–1117, 2013. View at Publisher · View at Google Scholar · View at Scopus
  133. M. Giannelli, F. Chellini, C. Sassoli et al., “Photoactivation of bone marrow mesenchymal stromal cells with diode laser: effects and mechanisms of action,” Journal of Cellular Physiology, vol. 228, no. 1, pp. 172–181, 2013. View at Publisher · View at Google Scholar · View at Scopus
  134. K. Choi, B.-J. Kang, H. Kim et al., “Low-level laser therapy promotes the osteogenic potential of adipose-derived mesenchymal stem cells seeded on an acellular dermal matrix,” Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol. 101, no. 6, pp. 919–928, 2013. View at Publisher · View at Google Scholar · View at Scopus
  135. B. S. Alexandrov, M. L. Phipps, L. B. Alexandrov et al., “Specificity and heterogeneity of terahertz radiation effect on gene expression in mouse mesenchymal stem cells,” Scientific Reports, vol. 3, article 1184, 2013. View at Publisher · View at Google Scholar · View at Scopus
  136. B. S. Alexandrov, K. Ø. Rasmussen, A. R. Bishop et al., “Non-thermal effects of terahertz radiation on gene expression in mouse stem cells,” Biomedical Optics Express, vol. 2, no. 9, pp. 2679–2689, 2011. View at Publisher · View at Google Scholar · View at Scopus
  137. J. Bock, Y. Fukuyo, S. Kang et al., “Mammalian stem cells reprogramming in response to terahertz radiation,” PLoS ONE, vol. 5, no. 12, Article ID e15806, 2010. View at Publisher · View at Google Scholar · View at Scopus
  138. Y. H. Wu, J. Wang, D. X. Gong, H. Y. Gu, S. S. Hu, and H. Zhang, “Effects of low-level laser irradiation on mesenchymal stem cell proliferation: a microarray analysis,” Lasers in Medical Science, vol. 27, no. 2, pp. 509–519, 2012. View at Publisher · View at Google Scholar · View at Scopus
  139. J.-Y. Wu, Y.-H. Wang, G.-J. Wang et al., “Low-power GaAlAs laser irradiation promotes the proliferation and osteogenic differentiation of stem cells via IGF1 and BMP2,” PLoS ONE, vol. 7, no. 9, Article ID e44027, 2012. View at Publisher · View at Google Scholar · View at Scopus
  140. J. Wang, W. Huang, Y. Wu et al., “MicroRNA-193 pro-proliferation effects for bone mesenchymal stem cells after low-level laser irradiation treatment through inhibitor of growth family, member 5,” Stem Cells and Development, vol. 21, no. 13, pp. 2508–2519, 2012. View at Publisher · View at Google Scholar · View at Scopus
  141. M. Soleimani, E. Abbasnia, M. Fathi, H. Sahraei, Y. Fathi, and G. Kaka, “The effects of low-level laser irradiation on differentiation and proliferation of human bone marrow mesenchymal stem cells into neurons and osteoblasts-an in vitro study,” Lasers in Medical Science, vol. 27, no. 2, pp. 423–430, 2012. View at Publisher · View at Google Scholar · View at Scopus
  142. I. Saygun, N. Nizam, A. U. Ural, M. A. Serdar, F. Avcu, and T. F. Tözüm, “Low-level laser irradiation affects the release of basic fibroblast growth factor (bFGF), insulin-like growth factor-I (IGF-I), and receptor of IGF-I (IGFBP3) from osteoblasts,” Photomedicine and Laser Surgery, vol. 30, no. 3, pp. 149–154, 2012. View at Publisher · View at Google Scholar · View at Scopus
  143. H. Kim, K. Choi, O.-K. Kweon, and W. H. Kim, “Enhanced wound healing effect of canine adipose-derived mesenchymal stem cells with low-level laser therapy in athymic mice,” Journal of Dermatological Science, vol. 68, no. 3, pp. 149–156, 2012. View at Publisher · View at Google Scholar · View at Scopus
  144. H. Abrahamse, “Regenerative medicine, stem cells, and low-level laser therapy: future directives,” Photomedicine and Laser Surgery, vol. 30, no. 12, pp. 681–682, 2012. View at Publisher · View at Google Scholar · View at Scopus
  145. B. Mvula, T. Mathope, T. Moore, and H. Abrahamse, “The effect of low level laser irradiation on adult human adipose derived stem cells,” Lasers in Medical Science, vol. 23, no. 3, pp. 277–282, 2008. View at Publisher · View at Google Scholar · View at Scopus
  146. B. Mvula, T. J. Moore, and H. Abrahamse, “Effect of low-level laser irradiation and epidermal growth factor on adult human adipose-derived stem cells,” Lasers in Medical Science, vol. 25, no. 1, pp. 33–39, 2010. View at Publisher · View at Google Scholar · View at Scopus
  147. J. A. de Villiers, N. N. Houreld, and H. Abrahamse, “Influence of low intensity laser irradiation on isolated human adipose derived stem cells over 72 hours and their differentiation potential into smooth muscle cells using retinoic acid,” Stem Cell Reviews and Reports, vol. 7, no. 4, pp. 869–882, 2011. View at Publisher · View at Google Scholar · View at Scopus
  148. L. Abramovitch-Gottlib, T. Gross, D. Naveh et al., “Low level laser irradiation stimulates osteogenic phenotype of mesenchymal stem cells seeded on a three-dimensional biomatrix,” Lasers in Medical Science, vol. 20, no. 3-4, pp. 138–146, 2005. View at Publisher · View at Google Scholar · View at Scopus