Generating Diverse Spinal Motor Neuron Subtypes from Human Pluripotent Stem Cells

Figure 4

A schematic depicting columnar arrangement of motor neuron subtypes in relation to different rostrocaudal portions of the neuraxis. The LMCs exist only at cervical (brachial) and lumbar foci and are responsible for innervating the muscles of the upper and lower limbs, respectively. The MMC exists throughout the rostrocaudal extent of the spinal cord and is responsible for innervating axial musculature. The HMC and PGC exist only in thoracic portions of the spinal cord and innervate the intercostal musculature and sympathetic ganglia, respectively. R-C: rostrocaudal; LMC: lateral motor column; MMC: medial motor column; HMC: hypaxial motor column; PGC: preganglionic motor column; MN: motor neuron.