The Therapeutic Targets of miRNA in Hepatic Cancer Stem Cells

Table 1

Cell surface marker of hepatic cancer stem cells.

Marker	Localization	Structure	Role in cancer	Ref.
CD133; (prominin 1)	Adult stem cells	Pentaspan transmembrane glycoprotein	Self-renewal, tumorigenicity, chemoresistance, and invasiveness	[23, 24]
CD90; (Thy-1)	Adult stem cells	Glycosyl-PI-anchored glycoprotein	Tumor formation, self-renewal, and metastasis	[25]
CD44	Mammalian cell types	Cell surface-glycoprotein	Tumor formation, chemoresistance, and metastatic ability	[26]
CD13	Predominantly on cells in G1/G0 phase	Zn^2+ dep. Membrane bound ectopeptidase	Tumorigenicity, cell proliferation, self-renewal, and chemoresistance	[27]
CD24; (HAS)	Differentiating cells	Cell adhesion glycoprotein	Self-renewal, tumor formation, metastasis, and chemoresistance	[28]
OV6	Oval cells in fetal liver	Surface antigen	Tumor formation and chemoresistance	[29]
DLK1	Stem/progenitor hepatic and fetal liver cells	—	Proliferation, self-renewal, tumor formation, and tumor growth	[30]
EpCAM	Progenitors and stem cells	Transmembrane glycoprotein	Invasiveness, self-renewal, and tumor formation	[31]
GEP	Fetal liver	Hepatic oncofetal protein	Tumorigenicity and chemoresistance	[32]
SP; (side population)	Cell subpopulation efflux chemotherapy drugs through ABC transporters	—	Tumorigenicity, self-renewal, and chemoresistance	[33]