Research Article

Dexamethasone Regulates EphA5, a Potential Inhibitory Factor with Osteogenic Capability of Human Bone Marrow Stromal Cells

Table 3

Genes downregulated in hBMSCs by DEX treatment. Human genes downregulated by at least threefold in hBMSCs treated with DEX for 6 h at P5 compared with nontreated cells.

Genes GenebankLog2 ratio

EGR2Early growth response 2 (Krox-20 homolog, Drosophila), transcript variant 1NM_000399−4.446
CXCL1Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) NM_001511−4.060
EGR1Early growth response 1 NM_001964−3.989
CXCL2Chemokine (C-X-C motif) ligand 2NM_002089−3.925
ATF3Activating transcription factor 3, transcript variant 4NM_001040619−3.847
EGR3Early growth response 3 NM_004430−3.382
NR4A1Nuclear receptor subfamily 4, group A, member 1, transcript variant 1NM_002135−3.312
IER3Immediate early response 3NM_003897−3.294
SERTAD4SERTA domain containing 4 NM_019605−3.142
FOSv-fos FBJ murine osteosarcoma viral oncogene homolog NM_005252−3.050
FOSBFBJ murine osteosarcoma viral oncogene homolog B, transcript variant 1NM_006732−3.042
CXCL3Chemokine (C-X-C motif) ligand 3NM_002090−2.950
ZC3H12AZinc finger CCCH-type containing 12A NM_025079−2.949
IL-8Interleukin-8NM_000584−2.917
GDF15Growth differentiation factor 15NM_004864−2.887
IL-6Interleukin-6 (interferon, beta 2)NM_000600−2.886
MAP3K8Mitogen-activated protein kinase kinase kinase 8NM_005204−2.837
BTG2BTG family, member 2NM_006763−2.669
SEMA6DSema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, transcript variant 6NM_024966−2.659
PTGS2Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) NM_000963−2.586
HES1Hairy and enhancer of split 1, (Drosophila) NM_005524−2.520
HAS3Hyaluronan synthase 3, transcript variant 2NM_138612−2.502
NCOA7Nuclear receptor coactivator 7, transcript variant 1NM_181782−2.390
EYA1Eyes absent homolog 1 (Drosophila), transcript variant 3NM_000503−2.376
JUNBJun B proto-oncogeneNM_002229−2.356
C10orf10Chromosome 10 open reading frame 10 (C10orf10)NM_007021−2.347
PIM1Pim-1 oncogene NM_002648−2.316
ST8SIA1ST8 alpha-N-acetyl-neuraminidase alpha-2,8-sialyltransferase 1 NM_003034−2.256
C5orf41Chromosome 5 open reading frame 41 (C5orf41)NM_153607−2.251
KLHL24Kelch-like 24 (Drosophila) NM_017644−2.248
JUNJun oncogeneNM_002228−2.247
BCL2L11BCL2-like 11 (apoptosis facilitator), transcript variant 1NM_138621−2.227
EBF3Early B-cell factor 3NM_001005463−2.195
NFκBIZNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta, transcript variant 1NM_031419−2.188
AMOTL2Angiomotin like 2 NM_016201−2.160
TOXThymocyte selection-associated high mobility group box NM_014729−2.149
NUAK2NUAK family, SNF1-like kinase, 2NM_030952−2.112
SASH1SAM and SH3 domain containing 1NM_015278−2.112
SLC40A1Solute carrier family 40 (iron-regulated transporter), member 1NM_014585−2.102
CCL2Chemokine (C-C motif) ligand 2 NM_002982−2.089
ID4Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein NM_001546−2.034
FAM110BFamily with sequence similarity 110, member B NM_147189−2.030
AXUD1AXIN1 upregulated 1NM_033027−2.014
BCL3B-cell CLL/lymphoma 3NM_005178−2.011
ARL4CADP-ribosylation factor-like 4CNM_005737−2.011
IER2Immediate early response 2NM_004907−2.009
RASD1RAS, dexamethasone-induced 1 NM_016084−2.007
OSR2Odd-skipped related 2 (Drosophila), transcript variant 2NM_053001−1.985
GAB1GRB2-associated binding protein 1, transcript variant 1NM_207123−1.977
TNFAIP3Tumor necrosis factor, alpha-induced protein 3 NM_006290−1.954
PDK4Pyruvate dehydrogenase kinase, isozyme 4 NM_002612−1.930
BMP4Bone morphogenetic protein 4, transcript variant 1NM_001202−1.867
BDKRB1Bradykinin receptor B1 NM_000710−1.849
IRF1Interferon regulatory factor 1NM_002198−1.840
N4BP2L1NEDD4 binding protein 2-like 1, transcript variant 1NM_052818−1.814
ARHGAP20Rho GTPase activating protein 20NM_020809−1.802
NFκBIANuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha NM_020529−1.801
CXCR7Chemokine (C-X-C motif) receptor 7 NM_020311−1.789
RFTN2Raftlin family member 2 NM_144629−1.774
PRICKLE1Prickle homolog 1 (Drosophila)NM_153026−1.768
TIAM2T-cell lymphoma invasion and metastasis 2, transcript variant 1NM_012454−1.753
BIRC3Baculoviral IAP repeat-containing 3, transcript variant 1NM_001165−1.751
C5orf4Chromosome 5 open reading frame 4, transcript variant 2NM_032385−1.731
GATA6GATA binding protein 6NM_005257−1.729
CLDN23Claudin 23NM_194284−1.719
TNFRSF11BTumor necrosis factor receptor superfamily, member 11b NM_002546−1.700
C2orf67Homo sapiens chromosome 2 open reading frame 67 (C2orf67), mRNA [NM_152519]NM_152519−1.693
TRIB3Tribbles homolog 3 (Drosophila)NM_021158−1.693
EBF1Early B-cell factor 1NM_024007−1.684
PRAGMINHomolog of rat pragma of Rnd2NM_001080826−1.683
MAFBv-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) NM_005461−1.680
ZFP36Zinc finger protein 36, C3H type, homolog (mouse) NM_003407−1.673
IL-7Interleukin-7 NM_000880−1.642
RUNX1T1Runt-related transcription factor 1; translocated to, 1 (cyclin D-related), transcript variant 1NM_004349−1.628
HK2Hexokinase 2 NM_000189−1.623

EPHA5EPH receptor A5, transcript variant 1NM_004439−1.186

A total of 28,780 human genes consistent with the quality criteria, genes downregulated twofold or higher are listed.