Emerging Implications for Extracellular Matrix-Based Technologies in Vascularized Composite Allotransplantation

Figure 2

Implantable devices for drug localized delivery. Minimally invasive implantation of drug eluting biomaterials offers advantages over oral drug regimens including localized drug delivery, minimizing or eliminating systemic side effects, and overcoming the barrier of patient noncompliance. (a) Graft implanted biomaterials release active drugs or prodrugs in controlled fashion upon in vivo degradation directly into the local tissue microenvironment. (b) Pharmacokinetic profiles of oral medication versus. (c) Implantable drug eluting materials. Additional advantages include reduced dosing, frequency and duration of dosing, favorable drug kinetics and maintenance of pharmacologic agents within the therapeutic window limiting systemic exposure.

(a)

(b)

(c)