Research Article

Mutation-Specific Phenotypes in hiPSC-Derived Cardiomyocytes Carrying Either Myosin-Binding Protein C Or α-Tropomyosin Mutation for Hypertrophic Cardiomyopathy

Table 3

AP properties of ventricular-like CMs derived from control hiPSC lines (WT) and from hiPSC lines carrying TPM1-Asp175Asn (HCMT) or MYBPC3-Gln1061X (HCMM) mutations. In the results, the data of each group is comprised from two separate cell lines.

GroupBeating rateAPD50APD90APAMDP
(BPM)(ms)(ms)(mV)(mV)

WT4358.1 ± 2.3277.3 ± 13.0323.6 ± 13.9119.5 ± 1.1−76.8 ± 0.8
HCMT7148.4 ± 1.5372.3 ± 13.2433.1 ± 14.0121.2 ± 1.1−75.8 ± 0.7
HCMM5447.1 ± 1.8319.5 ± 13.7377.6 ± 15.0124.3 ± 1.4−77.9 ± 0.8

HCMT or HCMM versus WT.
HCMM versus HCMT.
or and .