Wnt5a Increases Properties of Lung Cancer Stem Cells and Resistance to Cisplatin through Activation of Wnt5a/PKC Signaling Pathway

Figure 1

Wnt5a promotes lung cancer cell proliferation. Lung cancer cell line A549 and A549/DDP cells were cultured in 96-well plate at a density of per well and cultured in Wnt5a-CM and/or medium containing GF109203X. The proliferation of cells was then determined in terms of CCK assay. (a) The cell proliferation in A549 cells in the absence or presence of cisplatin. (b) The cell proliferation in A549/DDP cells in the absence or presence of cisplatin. Wnt5a showed an ability to promote cell proliferation, and GF109203X inhibited the Wnt5a-induced proliferation. Wnt5a-CM could increase cell proliferation in A549 and A549/DDP cells. Compared to a Control-CM treated control cells, represents . Data represented the mean ± SD from three independent triplicated experiments (). GF: GF109203X.

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