Wnt5a Increases Properties of Lung Cancer Stem Cells and Resistance to Cisplatin through Activation of Wnt5a/PKC Signaling Pathway

Figure 9

A schematic model to summarize Wnt5/PKC signaling pathway in lung cancer. Wnt5a activates PKC signaling and leads to endoplasmic reticulum (ER) release of Ca²+; PKC and CaMKII are activated, which in turn activate NFB. Subsequently, the activated NFB signaling promotes stem cell properties and inhibits apoptosis in lung cancer. CaMK: calcium/calmodulin kinase; FZD: Frizzled; PKC: protein kinase C; Ror: receptor tyrosine kinase-like orphan receptor.