Long Noncoding RNA Regulation of Pluripotency

Figure 2

linc-RoR as a paradigm for lncRNA regulation of pluripotency in the cytoplasm. In pluripotent cells, the levels of linc-RoR are controlled by OCT4. In a positive feedback loop, linc-RoR sponges miR-145, thus derepressing its targets, including OCT4. OCT4 also negatively controls miR-145 at the transcriptional level [41, 59–61]. See text for details.