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Stem Cells International
Volume 2016, Article ID 1859567, 7 pages
Review Article

Immunotolerant Properties of Mesenchymal Stem Cells: Updated Review

Division of Cardiac Surgery, Health Sciences North, Sudbury, ON, Canada

Received 29 July 2015; Revised 3 October 2015; Accepted 11 October 2015

Academic Editor: Eva Mezey

Copyright © 2016 Whitney Faiella and Rony Atoui. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Stem cell transplantation is a potential therapeutic option to regenerate damaged myocardium and restore function after infarct. Current research is focused on the use of allogeneic mesenchymal stem cells (MSCs) due to their unique immunomodulatory characteristics and ability to be harvested from young and healthy donors. Both animal and human studies support the immunoprivileged state of MSCs and even demonstrate improvements in cardiac function after transplantation. This research continues to be a topic of interest, as advances will ultimately enable the clinical use of these universal cells for therapy after a myocardial infarction. Updated in vitro, in vivo, and clinical trial studies are discussed in detail in the following review.