Review Article
The Modulatory Effects of Mesenchymal Stem Cells on Osteoclastogenesis
Table 1
Studies addressing the effects of MSCs on osteoclastogenic culture systems.
| | Reference | Source of cells | Osteoclast precursors | Supplemented factors which support osteoclastogenesis | Osteoclastogenesis related factors secreted by MSCs | | RANKL | M-CSF | 1,25(OH)2D3 | Others |
| | [39] | Human |
CD34+ HSCs | — | — | None or 10−9 or 10−8 M | | IL-6, IL-11, M-CSF, stem cell factor, and LIF | | [121] | Mice | Bone marrow cells | — | — | +ve | Prostaglandin E2 | — | | [122] | Mice |
CD11b+ monocytes | None or 10 or 20 ng/mL | 10 or 20 ng/mL | — | TNF may be present | RANKL, M-CSF, IL-6, and OPG | | [126] | Human | PBMCs | 50 ng/mL | 50 ng/mL | None or 10−7 M | | OPG | | [141] | Human | PBMCs | 50 ng/mL | 50 ng/mL | — | | — | | [127] | Rats | Bone marrow cells | — | — | 10−8 M | htROSCM was added to the culture media | TGF-β1, OPG, and IL-10 |
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