Enhanced Osteogenic and Vasculogenic Differentiation Potential of Human Adipose Stem Cells on Biphasic Calcium Phosphate Scaffolds in Fibrin Gels
ASC proliferation and osteogenic differentiation in BCP60/40- and BCP20/80-based composites and fibrin gels at day 1 and 11 of culture. (a) Total DNA content in BCP60/40- and BCP20/80-based composites and fibrin gels. The increase in total DNA content from day 1 to day 11 was significantly higher in BCP60/40- and BCP20/80-based composites compared to fibrin gels, indicating similar proliferation in both composites, but increased proliferation in both composites compared to fibrin gels. (b) ALP activity in BCP60/40- and BCP20/80-based composites and fibrin gels. BCP20/80-based composites showed higher ALP activity compared to BCP60/40-based composites at day 11. ALP activity of both BCP60/40- and BCP20/80-based composites was higher compared to fibrin gels at days 1 and 11. Values are mean ± SEM (–12).Significant effect of BCP60/40- or BCP20/80-based composites compared to fibrin gels, .Significantly different from BCP60/40-based composites, . BCP, biphasic calcium phosphate; ALP, alkaline phosphatase.
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