Enhanced Osteogenic and Vasculogenic Differentiation Potential of Human Adipose Stem Cells on Biphasic Calcium Phosphate Scaffolds in Fibrin Gels
Gene expression of the vasculogenic differentiation markers CD31, VEGF165 and VEGF189, and EDN1 in BCP60/40- and BCP20/80-based composites, and fibrin gels at days 1, 7, and 11 of culture. (a) BCP20/80-based composites showed increased CD31 gene expression compared to BCP60/40-based composites at day 11, as well as to fibrin gels. (b) BCP60/40- and BCP20/80-based composites demonstrated similar VEGF165 gene expression at all time points. (c) BCP20/80-based composites showed increased VEGF189 gene expression compared to BCP60/40-based composites at days 1 and 7. (d) BCP60/40- and BCP20/80-based composites showed similar EDN1 gene expression at all time points. Values are mean ± SEM (–12).Significant effect of BCP60/40- or BCP20/80-based composites compared to fibrin gels, .Significantly different from BCP60/40-based composites, . BCP, biphasic calcium phosphate; CD31, cluster of differentiation-31; VEGF165, vascular endothelial growth factor-165; VEGF189, vascular endothelial growth factor-189; EDN1, endothelin-1.
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