Senescence-Associated Molecular and Epigenetic Alterations in Mesenchymal Stem Cell Cultures from Amniotic Fluid of Normal and Fetus-Affected Pregnancy

<div>Epigenetic changes during passaging of MSCs cultures derived from AF of normal and pathological gestation. Lysates from cell samples of healthy (N) donors (D) and with fetal abnormalities (P) were subjected to Western blot analysis to monitor the expression of proteins using the indicated antibodies. (a, b) Representative blots of proteins from cell cultures of two groups (I and II) during culturing at passages 4, 6, and 8 and (c) from cell cultures derived from AF of normal gestation (D1) and individual donors (D2–D4) carrying fetus abnormalities. The data is representative of at least two gels showing similar results.</div>

Stem Cells International

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Figure 5: Senescence-Associated Molecular and Epigenetic Alterations in Mesenchymal Stem Cell Cultures from Amniotic Fluid of Normal and Fetus-Affected Pregnancy 

Figure 5 | Senescence-Associated Molecular and Epigenetic Alterations in Mesenchymal Stem Cell Cultures from Amniotic Fluid of Normal and Fetus-Affected Pregnancy 