High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis

Table 4

Categorizing compounds based on their degree of injury at isomolar concentration of 100 µM for each parameter measured.

Degree of injury	hiPSC derived hepatocytes	HepG2
Severe hepatotoxicity	Amiodarone HCl	Amiodarone HCl
Moderate hepatotoxicity	Doxycycline
Mild hepatotoxicity	Tetracycline HCl	Doxycycline, tetracycline HCl, sodium citrate
Nontoxic	Sodium citrate

Refer supplementary-I Table for the scoring sheet on degree of injury calculation (see Supplementary Material available online at http://dx.doi.org/10.1155/2016/2475631).  Degree of injury measured at 125 µM for amiodarone.