Endothelial Progenitor Cell Migration-Enhancing Factors in the Secretome of Placental-Derived Mesenchymal Stem Cells

Figure 6

Characterization of PL-MSCs secretome. (a) Venn diagram illustrates the proteins presented in 100 kDa fraction of PL-MSCs conditioned medium as well as those presented in subfraction 5 and subfraction 6 of the 100 kDa fraction. Number of proteins presented in the 100 kDa fraction which were subsequently fractionated into subfraction 5 and/or subfraction 6 (labeled with white color) were regarded as candidate proteins. (b) Pie chart illustrates 239 candidate proteins which were further categorized into nonsecreted protein, classically secreted protein, and nonclassically secreted protein, by SignalP 4.1 and SecretomeP 2.0 software. (c) Graph demonstrates functions of 77 secretory proteins based on PANTHER classification and UniProt.

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