Pharmacological Inhibition of Gal-3 in Mesenchymal Stem Cells Enhances Their Capacity to Promote Alternative Activation of Macrophages in Dextran Sulphate Sodium-Induced Colitis
Pharmacological inhibition of Gal-3 in MSCs enhances their capacity to promote alternative activation of peritoneal macrophages. The significant increase in percentage of F4/80+CD206+ macrophages in MSCs + Davanat-treated Gal-3−/− macrophages (black bars), when compared to only MSCs-treated Gal-3−/− macrophages (white bars) (a). The percentage of F4/80+CD11b+ macrophages is shown (a). Representative flow cytometry dot plots are shown. The level of IL-10 and TGF-β in supernatants (b). Values are mean ± SEM ( per group). , .