Expression of BMP and Actin Membrane Bound Inhibitor Is Increased during Terminal Differentiation of MSCs
(a) Gene expression analysis of BAMBI and (b) BMP4 normalized to HPRT in MSC pellet cultures under chondrogenic and hypertrophy enhancing conditions analysed by real-time PCR. BAMBI and BMP4 are significantly upregulated under hypertrophic conditions compared to chondrogenic controls on days 17, 21, and 28. different donors, . (c) Western blot analysis of BAMBI: increased amount of BAMBI protein can be detected under hypertrophic conditions on days 21 and 28 compared to chondrogenic conditions.
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