Research Article
Endothelium-Independent Hypoxic Contraction Is Prevented Specifically by Nitroglycerin via Inhibition of Akt Kinase in Porcine Coronary Artery
Figure 3
Effects of 8-Br-cGMP on protein levels of Akt-p (S473) and total Akt. Akt-p (S473) level was significantly reduced after 8-Br-cGMP (10−4 M) treatment for 45 min (a) and this effect could be prevented by Rp-8-Br-PET-cGMPS (PKG-I, 3 × 10−5 M; (b)). The upper panels are western blots. The lower panels are the summaries of densitometric scanning of proteins expressed as ratio of Akt-p (S473) to total Akt. Data shown as means ± SEM; for each group. different from the control group (); different from the control group ().
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