The Interaction between Adult Cardiac Fibroblasts and Embryonic Stem Cell-Derived Cardiomyocytes Leads to Proarrhythmic Changes in In Vitro Cocultures

Figure 2

Effects of aCFs and MSCs on beating regularity of ESC-CMs during MEA measurements. Representative traces of aCF-ESC-CM (a) and MSC-ESC-CM (b) cocultures. ISIs of representative recordings of aCF-ESC-CM (c) and MSC-ESC-CM (d) cocultures. (e, f) Poincaré plots of representative measurements. No propagation block patterns could be identified as a potential cause of the increased beat-to-beat variability. Mean ISI was prolonged (g) and coefficient of variation was higher (h) in aCF-ESC-CM cocultures compared to MSC-ESC-CM cocultures. Data are expressed as mean ± SEM; .

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