Improved Protective Effect of Umbilical Cord Stem Cell Transplantation on Cisplatin-Induced Kidney Injury in Mice Pretreated with Antithymocyte Globulin

Table 3

Body weight, relative kidney weight, and renal function in BALB/cOlaHsd mice 4 days after cisplatin administration.

	Control	MSCs	ATG	ATG + MSCs	CIS	CIS + MSCs	ATG + CIS	ATG + CIS + MSCs
Body weight (g), day 0	27.3 ± 0.6	25.6 ± 1.2	27.6 ± 2.2	27.4 ± 2.7	24.9 ± 0.7	24.6 ± 0.8	26.6 ± 0.4	26.9 ± 0.3
Body weight change (g) (day 0–day 4)	0.9 ± 0.4	0.2 ± 0.2	0.3 ± 0.4	0.5 ± 0.4	(−); 5.1 ± 0.8	(−); 4.8 ± 0.5	(−); 4.8 ± 0.4	(−); 4.5 ± 0.9
Kidney relative weight ×100	1.68 ± 0.05	1.69 ± 0.06	1.67 ± 0.05	1.74 ± 0.05	1.71 ± 0.27	1.67 ± 0.17	1.79 ± 0.19	1.51 ± 0.06
BUN (mmol/L)	8.05 ± 0.77	7.43 ± 0.2	8.4 ± 0.47	6.95 ± 0.37	43.87 ± 6.57	42.7 ± 4.63	40.26 ± 6.84	31.34 ± 3.99
Creatinine (μmol/L)	30.5 ± 0.77	18.0 ± 0.2	18.25 ± 0.47	31.5 ± 7.63	83.67 ± 19.43	48.0 ± 16.83	42.0 ± 3.96	27.5 ± 1.91

ANOVA followed by Duncun multicomparison test; results are expressed as mean ± SEM; values with different superscript letters in rows are statistically different (). ATG + CIS + MSCs: cisplatin treated with single injection of MSCs pretreated with ATG, ATG + CIS: cisplatin, pretreated with ATG, ATG + MSCs: treated with single injection of MSCs pretreated with ATG, ATG: treated with ATG, CIS + MSCs: cisplatin treated with single injection of MSCs, CIS: cisplatin treated, and MSCs: treated with single injection of MSCs.