Osteosarcoma: Cells-of-Origin, Cancer Stem Cells, and Targeted Therapies

Figure 1

Cell-of-origin for OS. The figure shows the most relevant cell types present in the bone microenvironment. MSCs, represented in a perivascular niche, and their derived cell types along the osteogenic lineage, such as the osteoblasts (OSB), are strong candidates to acquire the first cancer-promoting mutations and initiate OS formation.