Comparison of the Biological Characteristics of Mesenchymal Stem Cells Derived from Bone Marrow and Skin

Table 2

Cytokine levels in the culture medium of MSCs isolated from the bone marrow and skin (pg/mL).

Group
Cytokine	Bone marrow (mean ± SD)	Skin (mean ± SD)	value	value
Cell proliferation-related cytokines
EGF	52.16 ± 10.75	301.35 ± 28.92	−36.125	<0.001
SCF	99.42 ± 31.08	231.55 ± 41.10	−11.469	<0.001
bFGF	110.09 ± 27.48	163.30 ± 53.16	−3.976	<0.001
VEGF	22.18 ± 7.18	590.22 ± 64.68	−39.037	<0.001
M-CSF	66.99 ± 32.33	206.31 ± 42.20	−11.720	<0.001
G-CSF	60.21 ± 16.70	141.13 ± 13.15	−17.028	<0.001
GM-CSF	167.44 ± 36.38	194.73 ± 26.72	−2.703	0.01
LIF	41.62 ± 8.25	28.42 ± 10.74	4.358	<0.001
TGF-β1	83.54 ± 35.28	395.16 ± 80.27	−15.894	<0.001
Inflammatory cytokines
IL-1	65.32 ± 21.71	36.29 ± 9.81	5.450	<0.001
IL-3	234.70 ± 34.81	67.03 ± 10.79	20.574	<0.001
IL-6	79.63 ± 12.65	61.67 ± 17.53	3.715	0.001
IL-7	90.24 ± 26.70	106.11 ± 21.93	−2.053	0.047
IL-8	55.22 ± 10.69	25.03 ± 4.56	11.614	<0.001
IL-11	124.19 ± 25.00	181.37 ± 31.74	−6.330	<0.001
HGF	57.43 ± 7.96	319.24 ± 41.03	−28.016	<0.001
TNF-α	24.26 ± 6.46	62.47 ± 12.41	−12.216	<0.001

EGF: epidermal growth factor; SCF: stem cell factor; bFGF: basic fibroblast growth factor; VEGF: vascular endothelial growth factor; M-CSF: macrophage colony-stimulating factor; G-CSF: granulocyte colony-stimulating factor; GM-CSF: granulocyte-macrophage colony-stimulating factor; LIF: leukemia inhibitory factor; TGF: transforming growth factor; IL: interleukin; HGF: hepatocyte growth factor; TNF: tumor necrosis factor. ; .