Stem Cells International / 2016 / Article / Tab 2 / Review Article
Regenerative Therapy of Type 1 Diabetes Mellitus: From Pancreatic Islet Transplantation to Mesenchymal Stem Cells Table 2 Resultant expression of key pancreatic transcription factors, hormones, and improvement of diabetes in vivo after differentiation of MSCs via chemical compounds.
Cell source PDX-1 FoxA2/HNF3β NGN-3 Pax-4 Pax-6 NeuroD Isl-1 Glut-2 GCK Insulin Glucagon Somatostatin C-peptide DTZ staining GSIS in vitro GSIS in vivo Ameliorates diabetes
Dave et al. 2014 [52 ]
Adipose tissue + ND ND ND + ND + ND ND + ND ND + ND + Tx human
Li et al. 2013 [53 ] + + ND ND + ND ND + ND + + Like basal + ND + ND ND
Marappagounder et al. 2013 [51 ] + ND + + ND ND + ND ND + ND ND ND + + ND ND
Mohamad Buang et al. 2012 [54 ] ND ND ND ND ND ND ND ND ND + ND ND ND + +
Chandra et al. 2011 [50 ] + + + + + + + + ND + + + + ND + + +
Timper et al. 2006 [49 ] + ND + ND Like basal ND + ND ND + + + + ND ND ND ND
Gabr et al. 2015 [56 ]
Bone marrow + (Tx) ND ND ND ND ND ND + (Tx) + (Tx) + (Tx) + (Tx) + (Tx) + (Tx) ND + (Tx) + (Tx)
Czubak et al. 2014 [55 ] ND ND ND ND ND ND ND ND ND ND ND ND + +
Jafarian et al. 2014 [57 ] + + + ND ND ND ND + ND + + + + + + Marappagounder et al. 2013 [51 ] + ND + + ND ND + ND ND + ND ND ND + + ND ND
ND = not determined, Tx after transplantation of MSC, and Tx (human) = recent clinical trial [61 ].
