Hijacking the Cellular Mail: Exosome Mediated Differentiation of Mesenchymal Stem Cells

Table 2

Two-week exosome mediated change in gene expression: 2D HMSC cultures.

Gene	HMSC regular exosomes fold change ( value)	HMSC Osteogenic exosomes fold change ( value)
Growth factors
BMP9	16.62 (0.01)	25.90 (0.02)
TGFB1	2.13 (0.04)	1.96 (0.04)
Transcription factors
RUNX2	1.08 (0.08)	1.17 (0.17)
ECM proteins
OCN	1.36 (0.06)	1.11 (0.27)
OPN	0.84 (0.21)	1.84 (0.01)

Data represent fold change in gene expression when regular and osteogenic exosomes isolated from 2-week cultures were incubated with HMSCs in 2D cultures for 48 hours. Data are presented as mean fold change in gene expression with respect to control. value specified in brackets shows statistical significance with respect to control obtained by means of Student’s -test.