Cancer Stem Cell Plasticity as Tumor Growth Promoter and Catalyst of Population Collapse

Figure 1

(a) Schematic of the proliferation potential erosion in the nonstem cancer cell (CC) population after asymmetric division of cancer stem cell (CSC) that occurs with probability . (b) Schematic of cellular differentiation and dedifferentiation (probabilities and , resp.), in which the proliferation potential is memorized in course of evolution. (c) Schematic of the simulation procedure and cell cycle evaluations.

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