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Stem Cells International
Volume 2016, Article ID 4078215, 4 pages
http://dx.doi.org/10.1155/2016/4078215
Clinical Study

Stem Cell Mobilization with G-CSF versus Cyclophosphamide plus G-CSF in Mexican Children

1Banco de Sangre, Hospital General de Ecatepec las Américas, Simón Bolivar esq. Libertadores de América Fracc. las Américas, 55076 Ecatepec de Morelos, MEX, Mexico
2Area de Virología, Laboratorio de Microbiología y Enfermedades Infecciosas, Hospital Infantil de México Federico Gómez, Mexico
3Departamento de Oncología, Instituto Nacional de Pediatría, Mexico
4Laboratorio de Hematología e Investigación, Hospital General de México, OD and Laboratorio Clínico, Central Hospital Infantil de México Federico Gómez, Ciudad de México, DF, Mexico
5Departamento de Hematología Pediátrica, UMAE CMN la Raza IMSS, Mexico

Received 2 October 2015; Accepted 16 November 2015

Academic Editor: Mahendra S. Rao

Copyright © 2016 José Eugenio Vázquez Meraz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Fifty-six aphaereses were performed in 23 pediatric patients with malignant hematological and solid tumors, following three different protocols for PBPC mobilization and distributed as follows: A: seventeen mobilized with 4 g/m2 of cyclophosphamide (CFA) and 10 μg/kg/day of granulocyte colony stimulating factor (G-CSF), B: nineteen with CFA + G-CSF, and C: twenty only with G-CSF when the WBC count exceeded 10 × 109/L. The average number of MNC/kg body weight (BW)/aphaeresis was 0.4 × 108 (0.1–1.4), 2.25 × 108 (0.56–6.28), and 1.02 × 108 (0.34–2.5) whereas the average number of CD34+ cells/kg BW/aphaeresis was 0.18 × 106/kg (0.09–0.34), 1.04 × 106 (0.19–9.3), and 0.59 × 106 (0.17–0.87) and the count of CFU/kg BW/aphaeresis was 1.11 × 105 (0.31–2.12), 1.16 × 105 (0.64–2.97), and 1.12 × 105 (0.3–6.63) in groups A, B, and C, respectively. The collection was better in group B versus group A ( and , resp.) and in group C versus group A ( and , resp.). The collection of PBPCs was more effective in the group mobilized with CFM + G-CSF when the WBC exceeded 10 × 103/μL in terms of MNC and CD34+ cells and there was no toxicity of the chemotherapy.