Inhibition of Myocardial Ischemia/Reperfusion Injury by Exosomes Secreted from Mesenchymal Stem Cells

Table 1

The detail information of articles included.

Study	Country	Animals	The source of MSCs	Particles	Purification method	Injury	Experimental group treatment	Control group; treatment	Time point of extracting heart tissue	The time point of cardiac magnetic resonance; imaging	Route
Timmers et al., 2008 [11]	Netherlands	Pig	hESC	10–220 nm	MW cutoff	LCA occlusion for 75 min	1 mL MSC-CM; 4 mL MSC-CM	Saline	After 4 h of reperfusion	4 hours after reperfusion	Intracoronary injection
Lai et al., 2010 [13]	Singapore	Mouse	Fetal tissue	50–65 nm	HPLC	LCA occlusion for 30 min	10 μg protein of HPLC F1	200 μL saline	After 24 h of reperfusion	No	Via tail vein
Lai et al., 2010 [12]	Singapore	Mouse	HuES9.E1-derived	50–65 nm	HPLC	LCA; occlusion for 30 min	0.4 μg protein of HPLC F1	200 μL saline	After 24 h of reperfusion	No	Via tail vein
Arslan et al., 2013 [14]	Netherlands	Mouse	HuES9.E1-derived	Not shown	MWCO	LCA; occlusion for 30 min	0.4 μg/mL exosomes	Not shown	After 24 h of reperfusion	1, 7, 28 days after LCA	Not shown
Kang et al., 2015 [15]	USA	Rat	Rat bone marrow	40–90 nm	ExoQuick-TC	LCA occlusion; (time not shown)	Not shown	Not shown	Not shown	4 weeks after LCA	Not shown
Yu et al., 2015 [16]	USA	Rat	Rat bone marrow	100 nm	MWCO	LCA occlusion; (time not shown)	Not shown	Saline	Not shown	4 weeks after LCA	Intramyocardial injection

Animals were injected with CM twice: 5 min prior to the onset of reperfusion and immediately following reperfusion, respectively.