Aryl Hydrocarbon Receptor Deficiency in an Exon 3 Deletion Mouse Model Promotes Hematopoietic Stem Cell Proliferation and Impacts Endosteal Niche Cells

Table 1

AHR influences HSC characteristics.

Hematopoietic characteristics	AHR exon 2 KO mice (Bradfield) [14]	AHR exon 3 KO mice (Taconic Biosciences)
Platelet counts	NR	Increased
WBC count	Increased	Higher but NS
Granulocyte and monocyte population	Reduced	Increased but NS
RBC number	Reduced	No change
Liver weight	Reduced	Reduced
Spleen weight and cell number	Increased	Increased
Functional primitive progenitor colonies	Increased numbers	Increased numbers
LSK cells	Increased	Increased
LSK cell proliferation	Higher	Higher
Cell cycle status of LSK cells	Reduced G0/G1 phase; Increased G2/M phase	Reduced G0/G1 phase; Increased G2/M phase
LTHSC in BM	NR	Higher
Increased self-renewal of LTHSC (serial transplantation)	ND	Higher
Mesenchymal stem cells in endosteal niche	ND	Higher
Survival rate	Reduced	Reduced
Gene expression changes	Mtor (↑) Cebp (↑) Gfi1 (↓) Hes1 (↑) Stra13 (↓)	Mtor (↑) Cebp (↑) Gfi1 (↓) Hes1 (↑) Stra13 (↓)

The table depicts the difference and similarities between the two different strains of AHR-KO mice models (NR = not recorded, ND = not done, NS = not significant, (↑) = upregulation, and (↓) = downregulation).