Restoration of Polyamine Metabolic Patterns in In Vivo and In Vitro Model of Ischemic Stroke following Human Mesenchymal Stem Cell Treatment
Table 1
Polyamine levels in brain tissues from rats in the control group, group with transient MCAo, and the MCAo group following transplantation with hBM-MSCs.
Number
Compound
Polyamine levels (nmol, mean ± SD) in rat brain tissue (g)
Control group ()
Control + hBM-MSCs group ()
MCAo group ()
MCAo + hBM-MSCs group ()
value
1
N1-Acetylputrescine
374.7 ± 15.3
365.6 ± 12.0 (0.1)
382.3 ± 22.8 (0.2)
376.6 ± 15.0 (0.4)
0.3
2
N1-Acetylcadaverine
419.2 ± 17.7
408.3 ± 13.8 (0.1)
428.1 ± 26.9 (0.2)
421.1 ± 14.7 (0.4)
0.3
3
Putrescine
109.3 ± 5.0
107.4 ± 3.6 (0.2)
141.9 ± 14.2 (0.000003)
129.7 ± 13.6 (0.0003)
0.06
4
Cadaverine
59.5 ± 5.3
64.9 ± 11.9 (0.1)
73.7 ± 9.8 (0.0008)
62.4 ± 5.2 (0.1)
0.01
5
N1-Acetylspermidine
137.0 ± 9.9
145.1 ± 19.3 (0.1)
176.6 ± 24.4 (0.0002)
158.0 ± 25.7 (0.02)
0.1
6
N8-Acetylspermidine
231.8 ± 10.4
225.6 ± 6.9 (0.1)
244.2 ± 14.6 (0.03)
235.5 ± 9.3 (0.2)
0.1
7
Spermidine
172.6 ± 13.8
201.4 ± 13.4 (0.0003)
248.4 ± 44.3 (0.00006)
208.6 ± 37.6 (0.007)
0.05
8
N1-Acetylspermine
140.7 ± 24.2
138.2 ± 28.8 (0.4)
138.4 ± 20.5 (0.4)
130.7 ± 21.2 (0.2)
0.3
9
Spermine
513.6 ± 21.3
503.5 ± 19.4 (0.2)
520.7 ± 30.4 (0.3)
513.6 ± 18.4 (0.5)
0.3
Student’s -test at 95% confidence level on the mean values of control and control + hBM-MSCs groups. Student’s -test at 95% confidence level on the mean values of control and MCAo groups. Student’s -test at 95% confidence level on the mean values of control and MCAo + hBM-MSCs groups. Student’s -test at 95% confidence level on the mean values of MCAo and MCAo + hBM-MSCs groups.
