c-kit⁺AT₂R⁺ Bone Marrow Mononuclear Cell Subset Is a Superior Subset for Cardiac Protection after Myocardial Infarction

Figure 1

Flow cytometric analysis of BMMNCs. (a) FACS plots of c-kit⁺AT₂R⁺, sca-1⁺AT₂R⁺, and CD34⁺AT₂R⁺ cells isolated from MI and sham mice. (b) FACS plots were quantified as a percentage of AT₂R⁺ cells in total BMMNCs ( < 0.05, < 0.01 versus sham; values are means ± SEM; sham, = 6; MI, = 6). ((c)–(e)) Expression analysis of c-kit⁺AT₂R⁺ (c), sca-1⁺AT₂R⁺ (d), and CD34⁺AT₂R⁺ (e) in BMMNCs. Values are means ± SEM (sham, = 6; MI, = 6). (f) FACS plots of AT₂R⁺ cells isolated from human bone marrow. (g) Statistical expression analysis of AT₂R⁺ cells in total hBMMNCs ( < 0.05, versus other patients; values are means ± SEM (other patients, = 10; CABG patients, = 10)).

(a)

(b)

(c)

(d)

(e)

(f)

(g)